ArticleJournal of clinical biochemistry and nutrition2016
Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Carbonyl stress markers are associated with binge-eating/purging behavior of anorexia nervosa: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Association of Corneal Biomechanical Properties with Fingertip-Measured Advanced Glycation End Products and Carotenoids in Glaucoma Patients.Journal of clinical medicine · 2026Article
- Monoclonal antibody-based assay to identify compounds that inhibit NGlycoconjugate journal · 2025Article
- Fingertip skin autofluorescence as a non-invasive marker for vascular complications in patients with type 2 diabetes.Journal of diabetes investigation · 2025Article
- Accelerated Biological Aging in Exfoliation Glaucoma Assessed by Fundus-Derived Predicted Age and Advanced Glycation End Products.International journal of molecular sciences · 2025Article
- Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies.Antioxidants (Basel, Switzerland) · 2025Review
- Insights from the fructose-derived product glucoselysine: Revisiting the polyol pathway in diabetic complications.Journal of diabetes investigation · 2025Review
- Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes.Scientific reports · 2024Article
- Article
- Association between fingertip-measured advanced glycation end products and cardiovascular events in outpatients with cardiovascular disease.Cardiovascular diabetology · 2023Article
- The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD.Journal of clinical medicine · 2023Review
- Mitochondrial stress and glycoxidation increase with decreased kidney function.Journal of clinical biochemistry and nutrition · 2023Article
- A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers.Journal of clinical medicine · 2022Article
- Advanced Glycation End Products Are Associated with Diabetes Status and Physical Functions in Patients with Cardiovascular Disease.Nutrients · 2022Article
- Relevance of Diabetic Retinopathy with AGEs and Carotenoid Levels Assessed by Skin Sensors.Antioxidants (Basel, Switzerland) · 2022Article
- Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma.Antioxidants (Basel, Switzerland) · 2022Article
- Rapid pretreatment for multi-sample analysis of advanced glycation end products and their role in nephropathy.Journal of clinical biochemistry and nutrition · 2022Article
- Protein Modification with Ribose GeneratesInternational journal of molecular sciences · 2022Article
- Receptors of Advanced Glycation End Product (RAGE) Suppression Associated With a Preserved Osteogenic Differentiation in Patients With Prediabetes.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the accumulation of advanced glycation end-products (AGEs) of the Maillard reaction in our body is reported to increase with aging and is enhanced by the pathogenesis of lifestyle-related diseases such as diabetes, routine measurement of AGEs is not applied to regular clinical diagnoses due to the lack of conventional and reliable techniques for AGEs analyses. In the present study, a non-invasive AGEs measuring device was developed and the association between skin AGEs and diabetic complications was evaluated. To clarify the association between the duration of hyperglycemia and accumulation of skin fluorophores, diabetes was induced in mice by streptozotocin. As a result, the fluorophore in the auricle of live mice was increased by the induction of diabetes. Subsequent studies revealed that the fingertip of the middle finger in the non-dominant hand is suitable for the measurement of the fluorescence intensity by the standard deviation value. Furthermore, the fluorescence intensity was increased by the presence of diabetic microvascular complications. This study provides the first evidence that the accumulation of fluorophore in the fingertip increases with an increasing number of microvascular complications, demonstrating that the presence of diabetic microvascular complications may be predicted by measuring the fluorophore concentration in the fingertip.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.