ArticleJournal of clinical biochemistry and nutrition2016
Dietary zinc deficiency induces oxidative stress and promotes tumor necrosis factor-α- and interleukin-1β-induced RANKL expression in rat bone.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Cadmium, Iron Deficiency Anemia and Hypophosphatemic Osteomalacia Due to Intravenous Iron Supplementation.Biomedicines · 2026Review
- In Situ Biomineralization Enhances Mitochondrial Transplantation to Differentiating Osteoclast Precursors for Suppressing Cancer-Induced Osteolysis.Research (Washington, D.C.) · 2026Article
- Effects of short term dietary zinc deficiency and zinc supplementation on nitro-oxidative stress in testes of Wistar rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters.Biomolecules · 2024Review
- A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS.Reproductive biology and endocrinology : RB&E · 2023Review
- Influence of the Zinc and Fibre Addition in the Diet on Biomechanical Bone Properties in Weaned Piglets.Animals : an open access journal from MDPI · 2022Article
- Relationships Between Indicators of Metabolic Disorders and Selected Concentrations of Bioelements and Lead in Serum and Bone Tissue in Aging Men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Role of zinc in female reproduction.Biology of reproduction · 2021Review
- Oxidative stress specifically inhibits replication of dengue virus.The Journal of general virology · 2021Article
- Candy consumption may add to the body burden of lead and cadmium of children in Nigeria.Environmental science and pollution research international · 2019Article
- Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice.Scientific reports · 2017Article
- Changes of Bone-Related Minerals during Denosumab Administration in Post-Menopausal Osteoporotic Patients.Nutrients · 2017Article
- The Role of AOPP in Age-Related Bone Loss and the Potential Benefits of Berry Anthocyanins.Nutrients · 2017Review
- NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.American journal of physiology. Cell physiology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of dietary zinc deficiency on oxidative stress and bone metabolism. Four-week-old male Wistar rats were randomly assigned to one of three groups for 4 weeks: a zinc-adequate group (30 ppm); a zinc-deficient group (1 ppm); and a pair-fed group (30 ppm) that was pair-fed to the zinc-deficient group. The iron content and the thiobarbituric acid reactive substance level in bone were higher in the zinc-deficient group than in the zinc-adequate and pair-fed groups. The mRNA expression level of osteoblastogenesis-related genes such as bone morphogenetic protein 2 and runt-related transcription factor 2 was lower in the zinc-deficient group than in the zinc-adequate and pair-fed groups. In contrast, the mRNA expression levels of tumor necrosis factor-α, interleukin-1β and osteoclastogenesis-related genes such as receptor activator of nuclear factor-κB ligand and nuclear factor of activated T cells cytoplasmic 1 were higher in the zinc-deficient group than in the zinc-adequate and pair-fed groups. These findings suggested that dietary zinc deficiency reduced osteoblastogenesis via a decrease in the expression of bone morphogenetic protein 2 and increased osteoclastogenesis via enhancement of the expression of receptor for activator of nuclear factor-κB ligand induced by oxidative stress-stimulated tumor necrosis factor-α and interleukin-1β.
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