ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Sleep Modulation Alleviates Axonal Damage and Cognitive Decline after Rodent Traumatic Brain Injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in male healthy volunteers may reflect biomimetic sleep enhancement: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Auditory Stimulation of Slow-Wave Sleep Promotes Recovery after Brain Injury in an Animal Model.Annals of neurology · 2026Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
- Peg Forest Rehabilitation - A novel spatial navigation based cognitive rehabilitation paradigm for experimental neurotrauma.Behavioural brain research · 2023Article
- Electroencephalographic Changes in Sleep During Acute and Subacute Phases After Sports-Related Concussion.Nature and science of sleep · 2023Article
- Down-phase auditory stimulation is not able to counteract pharmacologically or physiologically increased sleep depth in traumatic brain injury rats.Journal of sleep research · 2022Article
- Technical feasibility of using auditory phase-targeted stimulation after pediatric severe traumatic brain injury in an intensive care setting.BMC pediatrics · 2022Article
- Circuits and components of delta wave regulation.Brain research bulletin · 2022Review
- Article
- Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila.PLoS biology · 2022Article
- Oral Administration ofJournal of fungi (Basel, Switzerland) · 2021Article
- Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans.Neurology · 2021Article
- Article
- Repetitive Mild Traumatic Brain Injury in Rats Impairs Cognition, Enhances Prefrontal Cortex Neuronal Activity, and Reduces Pre-synaptic Mitochondrial Function.Frontiers in cellular neuroscience · 2021Article
- Mild traumatic brain injury is associated with dysregulated neural network functioning in children and adolescents.Brain communications · 2021Article
- Resting-State Magnetoencephalography Source Imaging Pilot Study in Children with Mild Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- Brain white matter damage and its association with neuronal synchrony during sleep.Brain : a journal of neurology · 2019Article
- Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.Sleep · 2017Review
- A mouse Model of Focal Vascular Injury Induces Astrocyte Reactivity, Tau Oligomers, and Aberrant Behavior.Archives of neuroscience · 2017Article
- Does selection for short sleep duration explain human vulnerability to Alzheimer's disease?Evolution, medicine, and public health · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. It produces diffuse axonal injury (DAI), which contributes to cognitive impairment, but effective disease-modifying treatment strategies are missing. We have recently developed a rat model of closed skull TBI that reproduces human TBI consequences, including DAI and clinical sequelae such as memory impairment. Here, we investigated whether sleep modulation after trauma has an impact on DAI and memory outcome. We assessed cognition with the novel object recognition test and stained for amyloid precursor protein, a DAI marker. We found that both sleep induction and restriction acutely after TBI enhanced encephalographic slow-wave activity, markedly reduced diffuse axonal damage in the cortex and hippocampus, and improved memory impairment 2 weeks after trauma. These results suggest that enhancing slow-wave sleep acutely after trauma may have a beneficial disease-modifying effect in subjects with acute TBI. SIGNIFICANCE STATEMENT: Traumatic brain injury (TBI) is a clinically important entity. Cognitive deficits belong to the most prevalent chronic posttraumatic symptoms, most likely due to diffuse axonal injury (DAI). A growing body of evidence suggests a role of sleep in the clearance of waste products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI. In this study, we provide evidence that enhancement of slow-wave oscillatory activity in the delta-frequency range decreases the APP-immunoreactivity and preserves cognitive abilities after trauma, potentially offering novel, noninvasive treatment options for traumatic injury.
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