ArticleMalaria journal2016
Genomic signatures of population decline in the malaria mosquito Anopheles gambiae.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.BMC genomics · 2026Article
- Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control.Molecular ecology · 2026Article
- Article
- Must Epidemiologically Impactful Vector Control Interventions Disrupt Mosquito Population Structure? A Case Study of a Cluster-Randomised Controlled Trial.Evolutionary applications · 2025Article
- A new assay for molecular identification of Anopheles squamosus (Diptera: Culicidae) using internal transcribed spacer 2.Malaria journal · 2025Article
- Signatures of selection and mechanisms of insecticide resistance in UgandanbioRxiv : the preprint server for biology · 2025Article
- Genomic Analysis Reveals a New Cryptic Taxon Within the Anopheles gambiae Complex With a Distinct Insecticide Resistance Profile in the Coast of East Africa.Molecular ecology · 2025Article
- A Comprehensive Review: Biology ofInsects · 2025Review
- Considerations for first field trials of low-threshold gene drive for malaria vector control.Malaria journal · 2024Review
- Perspectives of African stakeholders on gene drives for malaria control and elimination: a multi-country survey.Malaria journal · 2023Article
- Contemporary NMolecular ecology resources · 2021Article
- Population Size, Sex and Purifying Selection: Comparative Genomics of Two Sister Taxa of the Wild Yeast Saccharomyces paradoxus.Genome biology and evolution · 2020Article
- Robust Estimation of Recent Effective Population Size from Number of Independent Origins in Soft Sweeps.Molecular biology and evolution · 2019Article
- The impact of Anopheles gambiae egg storage for mass rearing and production success.Malaria journal · 2019Article
- Growth-disrupting Murraya koenigii leaf extracts on Anopheles gambiae larvae and identification of associated candidate bioactive constituents.Acta tropica · 2019Article
- Comparative demography elucidates the longevity of parasitic and symbiotic relationships.Proceedings. Biological sciences · 2018Article
- Some like it hot: a differential response to changing temperatures by the malaria vectorsPeerJ · 2017Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation genomic features such as nucleotide diversity and linkage disequilibrium are expected to be strongly shaped by changes in population size, and might therefore be useful for monitoring the success of a control campaign. In the Kilifi district of Kenya, there has been a marked decline in the abundance of the malaria vector Anopheles gambiae subsequent to the rollout of insecticide-treated bed nets.
methodsTo investigate whether this decline left a detectable population genomic signature, simulations were performed to compare the effect of population crashes on nucleotide diversity, Tajima's D, and linkage disequilibrium (as measured by the population recombination parameter ρ). Linkage disequilibrium and ρ were estimated for An. gambiae from Kilifi, and compared them to values for Anopheles arabiensis and Anopheles merus at the same location, and for An. gambiae in a location 200 km from Kilifi.
resultsIn the first simulations ρ changed more rapidly after a population crash than the other statistics, and therefore is a more sensitive indicator of recent population decline. In the empirical data, linkage disequilibrium extends 100-1000 times further, and ρ is 100-1000 times smaller, for the Kilifi population of An. gambiae than for any of the other populations. There were also significant runs of homozygosity in many of the individual An. gambiae mosquitoes from Kilifi.
conclusionsThese results support the hypothesis that the recent decline in An. gambiae was driven by the rollout of bed nets. Measuring population genomic parameters in a small sample of individuals before, during and after vector or pest control may be a valuable method of tracking the effectiveness of interventions.
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