Evidence map›Paper›PMID 27013473›Full record

Trial reportBreast cancer research and treatment2016

Randomized sham-controlled pilot trial of weekly electro-acupuncture for the prevention of taxane-induced peripheral neuropathy in women with early stage breast cancer.

Heather Greenlee, Katherine D Crew, Jillian Capodice, Danielle Awad, Donna Buono, Zaixing Shi, Anne Jeffres, Sharon Wyse, Wendy Whitman, Meghna S Trivedi and 2 more

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 72 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 15 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03626220 nacompletednot on this mapstarted 2018, after this paper: background citation

Evaluation the Efficacy of Acupuncture in Chemotherapy Induced Peripheral Neuropathy

TypeinterventionalSponsorChina Medical University HospitalRan2018 to 2020Enrolled20ConditionsRandomized Controlled Trial, Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, AcupunctureArmsacupuncture
NCT05798884 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients: a Prospective, Randomized, Sham-controlled, Double-blinded and Multicenter Study

TypeinterventionalSponsorHong Kong Baptist UniversityRan2023 to 2025Enrolled150ConditionsColorectal Cancer, Oxaliplatin, Electro-acupuncture, NeurotoxicityArmsAcupuncture, Sham-acupuncture
NCT07455409 nacompletednot on this mapstarted 2019, after this paper: background citation

A Single-Arm Pilot Study of the Feasibility and Efficacy of Electro-Acupuncture in Subjects With Chemotherapy-Induced Peripheral Neuropathy

TypeinterventionalSponsorThe Methodist Hospital Research InstituteRan2019 to 2023Enrolled20ConditionsChemotherapy-induced Peripheral NeuropathyArmsElectro-acupuncture
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 15 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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  6. Acupuncture for radiation-induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Heather GreenleeMailman School of Public Health, Columbia University, New York, NY, USA. hg2120@columbia.edu.
Katherine D CrewMailman School of Public Health, Columbia University, New York, NY, USA.
Jillian CapodiceMount Sinai School of Medicine, New York, NY, USA.
Danielle AwadHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Donna BuonoMailman School of Public Health, Columbia University, New York, NY, USA.
Zaixing ShiMailman School of Public Health, Columbia University, New York, NY, USA.
Anne JeffresHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Sharon WyseHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Wendy WhitmanHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Meghna S TrivediCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kevin KalinskyHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Dawn L HershmanMailman School of Public Health, Columbia University, New York, NY, USA.
Columbia University · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · US

Funding

Effects of Antioxidant Supplementation during Breast Cancer Adjuvant TherapyK23CA141052 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENLEE, HEATHER · 2009 to 2013
$753k
NCI NIH HHS K23 CA141052NCI NIH HHS K23CA141052
6 · The paper itself

Abstract

To investigate the effect of electro-acupuncture (EA) as a non-pharmacological intervention to prevent or reduce chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients undergoing chemotherapy of taxane. Women with stage I-III breast cancer scheduled to receive taxane therapy were randomized to receive a standardized protocol of 12 true or sham EA (SEA) weekly treatments concurrent with taxane treatment. Subjects completed the Brief Pain Inventory-Short Form (BPI-SF), Functional Assessment of Cancer Therapy-Taxane neurotoxicity subscale (FACT-NTX), and other assessments at baseline and weeks 6, 12, and 16. A total of 180 subjects were screened, 63 enrolled and 48 completed week 16 assessments. Mean age was 50 with 25 % white, 25 % black, and 43 % Hispanic; 52 % had no prior chemotherapy. At week 12, both groups reported an increase in mean BPI-SF worst pain score, but no mean differences were found between groups (SEA 2.8 vs. EA 2.6, P = .86). By week 16, the SEA group returned to baseline, while the EA group continued to worsen (SEA 1.7 vs. EA 3.4, P = .03). The increase in BPI-SF worst pain score was 1.62 points higher in the EA group than in the SEA group at week 16 (P = .04). In a randomized, sham-controlled trial of EA for prevention of taxane-induced CIPN, there were no differences in pain or neuropathy between groups at week 12. Of concern, subjects on EA had a slower recovery than SEA subjects. Future studies should focus on EA for treatment as opposed to prevention of CIPN.

Indexed as

AdultAgedBreast NeoplasmsBridged-Ring CompoundsDouble-Blind MethodElectroacupunctureFemaleHumansMiddle AgedPeripheral Nervous System DiseasesPilot ProjectsTaxoidsTreatment OutcomeBridged-Ring CompoundstaxaneTaxoidsAcupunctureBreast cancerChemotherapy-induced peripheral neuropathyElectro-acupunctureTaxane

Identifiers

PMID27013473
PMCPMC4924571
OpenAlexW2310362320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.