Evidence map›Paper›PMID 27013342›Full record

ArticleThe American journal of psychiatry2016

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior.

Catherine Monk, Tianshu Feng, Seonjoo Lee, Izabela Krupska, Frances A Champagne, Benjamin Tycko

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04363177 (Mental Health of Urban Mothers), which is not on this map. Cited by 121 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 4 pooled it
56.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04363177 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Mental Health of Urban Mothers (MUM) Study: A Multi-center Randomized Controlled Trial

TypeinterventionalSponsorKarolinska InstitutetRan2022 to 2024Enrolled200ConditionsPerinatal Depression, COVID19, Anxiety, PTSDArmsWeb-based psychosocial peer-to-peer support
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 4 syntheses or guidelines pooled it, 308 citations in OpenAlex.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Catherine MonkFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Tianshu FengFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Seonjoo LeeFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Izabela KrupskaFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Frances A ChampagneFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Benjamin TyckoFrom the Department of Psychiatry, Columbia University Medical Center, New York; New York State Psychiatric Institute, New York; the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York; the Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York; Institute for Cancer Genetics, Columbia University Medical Center, New York; the Department of Psychology, Columbia University, New York; and the Department of Pathology and Cell Biology, Columbia University Medical Center, New York.
Columbia University Irving Medical Center · US

Funding

Prenatal stress: the epigenetic basis of maternal and perinatal effectsR01MH092580 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHAMPAGNE, FRANCES A., MONK, CATHERINE E · 2011 to 2015
$3.4M
NIMH NIH HHS R01 MH092580
6 · The paper itself

Abstract

objectiveIncreased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental glucocorticoid-pathway genes are potential mechanisms. The authors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate ("coupling") and DNA methylation of three glucocorticoid pathway genes-HSD11B2, NR3C1, and FKBP5-in term placentas.

methodMood questionnaires and salivary cortisol were collected from 61 women between 24-27 gestational weeks, and fetal assessment was conducted at 34-37 weeks. Placental CpG methylation in the three genes was analyzed using 450K Beadchips and bisulfite sequencing; correlations between maternal and fetal variables and DNA methylation were tested; and maternal distress effects on fetal behavior via DNA methylation were investigated.

resultsPerceived stress (Perceived Stress Scale), but not cortisol, was associated with altered CpG methylation in placentas. In the highest tertile of the Perceived Stress Scale, the Beadchip data revealed modestly elevated methylation of HSD11B2, associated with lower fetal coupling (β=-0.51), and modestly elevated methylation of FKBP5, also with lower fetal coupling (β=-0.47). These increases in methylation were validated by bisulfite sequencing, where they occurred in a minority of clones.

conclusionsThis is the first study to link the effects of pregnant women's distress on the fetus and epigenetic changes in placental genes. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells.

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1AdolescentAdultAnxiety DisordersArousalCpG IslandsDepressive DisorderDNA MethylationEpigenesis, GeneticFemaleFetal MovementHeart Rate, FetalHumansHydrocortisoneInfant, NewbornMood Disorders11-beta-Hydroxysteroid Dehydrogenase Type 1HSD11B1 protein, humanHydrocortisoneNR3C1 protein, humanReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding Proteins

Identifiers

PMID27013342
PMCPMC5026410
OpenAlexW2304339492

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.