ArticleDevelopment (Cambridge, England)2016
Regional signals in the planarian body guide stem cell fate in the presence of genomic instability.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The In Vitro Enhancement of Retinal Cell Viability via mInternational journal of molecular sciences · 2024Article
- The DNA methyltransferase DMAP1 is required for tissue maintenance and planarian regeneration.Developmental biology · 2024Article
- The DNA Methyltransferase DMAP1 is Required for Tissue Maintenance and Planarian Regeneration.bioRxiv : the preprint server for biology · 2024Article
- Purification of Planarian Stem Cells Using a Draq5-Based FACS Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Purification and transcriptomic characterization of proliferative cells ofFrontiers in parasitology · 2024Article
- Article
- Measuring DNA modifications with the comet assay: a compendium of protocols.Nature protocols · 2023Review
- Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation.Journal of cell science · 2022Article
- Analysis of DNA Double-Stranded Breaks Using the Comet Assay in Planarians.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites.eLife · 2021Article
- Whole planarian chromosome squash.STAR protocols · 2021Article
- Direct Current Electric Stimulation Alters the Frequency and the Distribution of Mitotic Cells in Planarians.Bioelectricity · 2021Article
- Article
- Poly(ADP-Ribose) Polymerase-3 Regulates Regeneration in Planarians.International journal of molecular sciences · 2020Article
- Article
- The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections.Developmental and comparative immunology · 2019Article
- DNA damage and tissue repair: What we can learn from planaria.Seminars in cell & developmental biology · 2019Review
- SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians.Cellular and molecular life sciences : CMLS · 2018Article
- The bioelectric code: An ancient computational medium for dynamic control of growth and form.Bio Systems · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cellular fate decisions are influenced by their topographical location in the adult body. For instance, tissue repair and neoplastic growth are greater in anterior than in posterior regions of adult animals. However, the molecular underpinnings of these regional differences are unknown. We identified a regional switch in the adult planarian body upon systemic disruption of homologous recombination with RNA-interference of Rad51 Rad51 knockdown increases DNA double-strand breaks (DSBs) throughout the body, but stem cells react differently depending on their location along the anteroposterior axis. In the presence of extensive DSBs, cells in the anterior part of the body resist death, whereas cells in the posterior region undergo apoptosis. Furthermore, we found that proliferation of cells with DNA damage is induced in the presence of brain tissue and that the retinoblastoma pathway enables overproliferation of cells with DSBs while attending to the demands of tissue growth and repair. Our results implicate both autonomous and non-autonomous mechanisms as key mediators of regional cell behavior and cellular transformation in the adult body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.