ArticleOsteoarthritis and cartilage2016
Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study.
Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review.Seminars in arthritis and rheumatism · 2023Pooled it
- The metabolome of male and female individuals with knee osteoarthritis is influenced by 18-months of weight loss intervention: the IDEA trial.BMC musculoskeletal disorders · 2024Trial
- Changes in the urinary metabolome accompanied alterations in body mass and composition in women with overweight - impact of high versus low protein breakfast.Metabolomics : Official journal of the Metabolomic Society · 2024Trial
- Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA).Osteoarthritis and cartilage · 2017Trial
- Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction.Cellular and molecular bioengineering · 2025Article
- Article
- Transcriptomics and metabolomics: Challenges of studying obesity in osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Metabolomics in Osteoarthritis Knee: A Systematic Review of Literature.Indian journal of orthopaedics · 2024Review
- Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies.Osteoarthritis and cartilage · 2024Review
- The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trial.bioRxiv : the preprint server for biology · 2024Article
- Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis.Frontiers in immunology · 2024Article
- Serum Metabolomic Alteration in Rats with Osteoarthritis Treated with Palm Tocotrienol-Rich Fraction Alone or in Combination with Glucosamine Sulphate.Life (Basel, Switzerland) · 2023Article
- DeepKOA: a deep-learning model for predicting progression in knee osteoarthritis using multimodal magnetic resonance images from the osteoarthritis initiative.Quantitative imaging in medicine and surgery · 2023Article
- Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis.Science advances · 2023Article
- Article
- Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis, With Obesity-Related Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis.Osteoarthritis and cartilage · 2022Article
- Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis.Journal of translational medicine · 2021Article
- A review of applications of metabolomics in osteoarthritis.Clinical rheumatology · 2021Review
- The microbiome mediates epiphyseal bone loss and metabolomic changes after acute joint trauma in mice.Osteoarthritis and cartilage · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
introductionMetabolic factors may contribute to osteoarthritis (OA). This study employed metabolomics analyses to determine if differences in metabolite profiles could distinguish people with knee OA who exhibited radiographic progression.
methodsUrine samples obtained at baseline and 18 months from overweight and obese adults in the Intensive Diet and Exercise for Arthritis (IDEA) trial were selected from two subgroups (n = 22 each) for metabolomics analysis: a group that exhibited radiographic progression (≥0.7 mm decrease in joint space width, JSW) and an age, gender, and body mass index (BMI) matched group who did not progress (≤0.35 mm decrease in JSW). Multivariate analysis methods, including orthogonal partial least square discriminate analysis, were used to identify metabolite profiles that separated progressors and non-progressors. Plasma levels of IL-6 and C-reactive protein (CRP) were evaluated as inflammatory markers.
resultsMultivariate analysis of the binned metabolomics data distinguished progressors from non-progressors. Library matching revealed that glycolate, hippurate, and trigonelline were among the important metabolites for distinguishing progressors from non-progressors at baseline whereas alanine, N,N-dimethylglycine, glycolate, hippurate, histidine, and trigonelline, were among the metabolites that were important for the discrimination at 18 months. In non-progressors, IL-6 decreased from baseline to 18 months while IL-6 was unchanged in progressors; the change over time in IL-6 was significantly different between groups.
conclusionThese findings support a role for metabolic factors in the progression of knee OA and suggest that measurement of metabolites could be useful to predict progression. Further investigation in a larger sample that would include targeted investigation of specific metabolites is warranted.
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