ArticleVirus genes2016
Growth characteristics and complete genomic sequence analysis of a novel pseudorabies virus in China.
Article in Virus genes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China.BMC genomics · 2024Article
- Development and immunogenicity evaluation of a quadruple-gene-deleted pseudorabies virus strain.Frontiers in microbiology · 2024Article
- The Immune Efficacy of Inactivated Pseudorabies Vaccine Prepared from FJ-2012ΔgE/gI Strain.Microorganisms · 2022Article
- The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.Viruses · 2022Review
- The Genetic Characterization of a Novel Natural Recombinant Pseudorabies Virus in China.Viruses · 2022Article
- Huaier Polysaccharide Interrupts PRV Infection via Reducing Virus Adsorption and Entry.Viruses · 2022Article
- The InactivatedFrontiers in microbiology · 2022Article
- Antiviral Activity ofOxidative medicine and cellular longevity · 2022Article
- Whole-Genome Sequence Analysis of Pseudorabies Virus Clinical Isolates from Pigs in China between 2012 and 2017 in China.Viruses · 2021Article
- Article
- Pseudorabies virus infection in hunting dogs in Oita, Japan: Report from a prefecture free from Aujeszky's disease in domestic pigs.The Journal of veterinary medical science · 2021Article
- Metabolomics Exploration of Pseudorabies Virus Reprogramming Metabolic Profiles of PK-15 Cells to Enhance Viral Replication.Frontiers in cellular and infection microbiology · 2020Article
- Implication of the Identification of an Earlier Pseudorabies Virus (PRV) Strain HLJ-2013 to the Evolution of Chinese PRVs.Frontiers in microbiology · 2020Article
- Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro.Pathogens (Basel, Switzerland) · 2019Article
- Article
- Intensive Distribution of G₂-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands.Molecules (Basel, Switzerland) · 2019Article
- Genetic characterization and mutation analysis of Qihe547 Aujeszky's disease virus in China.BMC veterinary research · 2018Article
- Identification and genetic characterization of porcine circovirus type 3 in China.Transboundary and emerging diseases · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Swine pseudorabies (PR) re-emerged in Bartha-vaccinated pig herds and caused death of millions of piglets in China since the later part of 2011. We isolated a novel pseudorabies virus (PRV), named HNX strain, from the brain of abortion fetuses to diagnose the disease. To reveal the genomic organization and characterize the HNX strain, the complete genomes of HNX and Fa strain, an isolate in the 1960s, were sequenced and analyzed. The genomic size of HNX and Fa strains were 142,294 and 141,930 nt, respectively, with corresponding G + C contents of 73.56 and 73.70 %. The two strains consistently possessed 70 open reading frames. In addition, comparative genomic analysis between HNX and Bartha strains was performed to understand the possible reason of immune failure. The major virulence-associated genes of HNX strain had slight changes, whereas glycoprotein B and glycoprotein C genes of HNX strain had 73 mutations; the homology at the whole genomic level between HNX and Bartha strains was 90.6 %. Genome-wide comparison between HNX and Fa strains indicated that the strains shared about 96.4 % of homology and clustered in a separate Chinese isolate group; the two strains are also distant from the isolates from other countries. Similarity plot and bootscanning analysis of complete genome sequences of nine PRV strains, including HNX and Fa, four newly Chinese strains, and three traditional reference strains, revealed that non-recombination events occurred in the HNX strain. The PRV HNX strain with genomic variations might contribute to the PR outbreak in China since the later part of 2011.
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