ArticleMolecular brain2016
Frequency-specific stimulations induce reconsolidation of long-term potentiation in freely moving rats.
Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- TMS and neocortical neurons: an integrative review on the micro-macro connection in neuroplasticity.Japanese journal of comprehensive rehabilitation science · 2023Review
- GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation.Scientific reports · 2021Article
- Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site.Biology open · 2020Article
- Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles.Molecular brain · 2019Article
- Autophagy Enhances Memory Erasure through Synaptic Destabilization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
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Authors and funding
6 authors.
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Abstract
backgroundWhen consolidated memories are retrieved, they become labile and a new protein synthesis-dependent reconsolidation process is required to restabilize these memories. So far, most studies conducted on reconsolidation rely on the analyses of animal behavior, leaving the synaptic mechanisms that underlie reconsolidation largely unclear. Here, we examined whether the reconsolidation process occurs in hippocampal long term potentiation (LTP), as a synaptic model that is correlated with long term memories (LTM).
resultsWe employed LTP system in the dentate gyrus of freely moving rats that lasts for weeks simulating LTM. LTP was induced by high frequency stimulation at 400 Hz (HFS400), and as a reactivation stimulation, we tested a low frequency stimulation at 0.1 Hz (LFS0.1), a theta stimulation at 8 Hz (TS8), or HFS400. Unlike HFS400 reactivation, both LFS0.1 and TS8 induced a reconsolidation-like phenomenon and rendered the LTP labile to protein synthesis inhibition by anisomycin. Without reactivation, LTP remained unaffected by protein synthesis inhibition. In addition, the TS8-induced LTP reconsolidation was NMDAR dependent.
conclusionOur results indicate that, as with behavioral LTM, there are boundary conditions for LTP reconsolidation where only a certain range of frequency stimulations as reactivation can destabilize the consolidated LTP. This LTP reconsolidation system will be useful for future elucidation of the synaptic reconsolidation mechanism.
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