ArticleBehavioural brain research2016
A murine model of peripheral irradiation-induced fatigue.
Article in Behavioural brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports.International journal of radiation oncology, biology, physics · 2018Pooled it
- Comprehensive review of mouse models for studying cancer-related fatigue: Methods, findings and future directions (Review).Experimental and therapeutic medicine · 2025Review
- The metabolic basis of cancer-related fatigue.Neuroscience and biobehavioral reviews · 2025Review
- Effects of acteoside fromFrontiers in pharmacology · 2024Article
- β-Endorphin mediates radiation therapy fatigue.Science advances · 2022Article
- ACancers · 2022Article
- Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice.Brain, behavior, & immunity - health · 2021Article
- Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila.Scientific reports · 2020Article
- Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression.PloS one · 2020Article
- Sublethal whole-body irradiation causes progressive premature frailty in mice.Mechanisms of ageing and development · 2019Article
- Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.Behavioural brain research · 2019Article
- Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.International journal of tryptophan research : IJTR · 2019Article
- Comparing passive measures of fatigue-like behavior in mice.Scientific reports · 2018Article
- Neuroimmunology of Behavioral Comorbidities Associated With Cancer and Cancer Treatments.Frontiers in immunology · 2018Review
- Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.Pharmacological research · 2017Article
- CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.Immunotherapy · 2017Review
- A Mouse Model of Fatigue Induced by Peripheral Irradiation.Journal of visualized experiments : JoVE · 2017Article
- Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model.Oncotarget · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeFatigue is the most ubiquitous side effect of cancer treatment, but its etiology remains elusive. Further investigations into cancer-related fatigue pathobiology necessitate the expanded use of animal models. This study describes the development of a murine model of radiation-induced fatigue.
methodsVoluntary wheel running activity measured fatigue in 5-8 week-old, male C57BL/6 mice before and after γ irradiation totaling 2400cGy (3 consecutive days×800cGy daily fractionated doses) to the lower abdominal areas. Three trials confirmed fatigue behavior at this dose. Anhedonia, body weight, and hemoglobin were also measured. Gastrointestinal, skeletal muscle, and bone marrow tissue samples were evaluated for signs of damage.
resultsIn two validation trials, irradiated mice (trial 1, n=8; trial 2, n=8) covered less cumulative distance in kilometers post-irradiation (trial 1, mean=115.3±12.3; trial 2, mean=113.6±21.8) than sham controls (trial 1, n=5, mean=126.3±5.7, p=0.05; trial 2, n=8, mean=140.9±25.4, p=0.02). Decreased mean daily running distance and speed were observed during the last four hours of the dark cycle in irradiated mice compared to controls for two weeks post-irradiation. There were no differences in saccharin preference or hemoglobin levels between groups, no effect of changes in body weight or hemoglobin on wheel running distance, additionally, histology showed no damage to muscle, bone marrow, or gastrointestinal integrity, with the latter confirmed by ELISA.
conclusionWe characterized a novel mouse model of fatigue caused by peripheral radiation and not associated with anemia, weight changes, or anhedonia. This model provides opportunities for detailed study of the mechanisms of radiation-induced fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.