Evidence map›Paper›PMID 27012252›Full record

ReviewTranslational behavioral medicine2016

Risk and resistance perspectives in translation-oriented etiology research.

Michael M Vanyukov, Ralph E Tarter, Kevin P Conway, Galina P Kirillova, Redonna K Chandler, Dennis C Daley

Abstract readReview
In one paragraph

Review in Translational behavioral medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. There is no stigmatization of substance use.Addiction research & theory · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Article
  6. Article
  7. Commentary on the Culture of Prevention.Prevention science : the official journal of the Society for Prevention Research · 2021
    Article
  8. Informing Prevention and Intervention Policy Using Genetic Studies of Resistance.Prevention science : the official journal of the Society for Prevention Research · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael M VanyukovUniversity of Pittsburgh, 3520 Forbes Ave., Suite 203, Pittsburgh, PA, 15213, USA. mmv@pitt.edu.ORCID http://orcid.org/0000-0003-4103-1260
Ralph E TarterUniversity of Pittsburgh, 3520 Forbes Ave., Suite 203, Pittsburgh, PA, 15213, USA.
Kevin P ConwayNational Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Galina P KirillovaUniversity of Pittsburgh, 3520 Forbes Ave., Suite 203, Pittsburgh, PA, 15213, USA.
Redonna K ChandlerNational Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Dennis C DaleyUniversity of Pittsburgh, 3520 Forbes Ave., Suite 203, Pittsburgh, PA, 15213, USA.

Funding

TRANSLATION MODULEP50DA005605 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RIDENOUR, TY A · 1989 to 2014
$25.7M
NIDA NIH HHS P50 DA005605
6 · The paper itself

Abstract

Risk for a disorder and the mechanisms that determine its elevation, risk factors, are the focus of medical research. Targeting risk factors should serve the goal of prevention and treatment intervention. Risk, however, is but one of the aspects of liability to a disorder, a latent trait that encompasses effects of all factors leading to or from the diagnostic threshold. The coequal but opposite aspect of liability is resistance to a disorder. The factors that increase resistance and thus enable prevention or recovery may differ from those that elevate risk. Accordingly, there are nontrivial differences between research perspectives that focus on risk and on resistance. This article shows how this distinction translates into goals and methods of research and practice, from the choice of potential mechanisms tested to the results sought in intervention. The resistance concept also differs from those of "resilience" and "protective factors," subsuming but not limited to them. The implications of the concept are discussed using substance use disorder as an example and substantiate the need for biomedical research and its translation to shift to the resistance perspective.

Indexed as

Disease SusceptibilityRiskHumansSubstance-Related DisordersTranslational Research, BiomedicalMalleabilityPhenotype measurementProtective factorsResearch paradigmResilience

Identifiers

PMID27012252
PMCPMC4807197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.