ArticleEnvironmental health : a global access science source2016
Ambient PM2.5 and risk of emergency room visits for myocardial infarction: impact of regional PM2.5 oxidative potential: a case-crossover study.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Systematic review and meta-analysis of case-crossover and time-series studies of short term outdoor nitrogen dioxide exposure and ischemic heart disease morbidity.Environmental health : a global access science source · 2020Pooled it
- Oxidative Potential Versus Biological Effects: A Review on the Relevance of Cell-Free/Abiotic Assays as Predictors of Toxicity from Airborne Particulate Matter.International journal of molecular sciences · 2019Pooled it
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- Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women's Health Initiative participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Residential factors associated with mental health in United States Veterans, Air Force military, and Air Force employees.Indoor environments · 2025Article
- The Dark Triad of Particulate Matter, Oxidative Stress and Coronary Artery Disease: What About the Antioxidant Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era.International journal of chronic obstructive pulmonary disease · 2025Article
- Air pollution mixture complexity and its effect on PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024Article
- Seasonal Changes in the Oxidative Potential of Urban Air Pollutants: The Influence of Emission Sources and Proton- and Ligand-Mediated Dissolution of Transition Metals.ACS ES&T air · 2024Article
- Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PMNature communications · 2024Article
- Exploring the Effects of Local Air Pollution on Popliteal Artery Aneurysms.Journal of clinical medicine · 2024Article
- Assessing the Oxidative Potential of Outdoor PMACS ES&T air · 2024Article
- Long-term ozone exposure and mortality in patients with chronic kidney disease: a large cohort study.BMC nephrology · 2024Article
- Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Personal exposure to PMJournal of exposure science & environmental epidemiology · 2023Article
- Applying principal component pursuit to investigate the association between source-specific fine particulate matter and myocardial infarction hospitalizations in New York City.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Fine particulate matter and incident coronary heart disease events up to 10 years of follow-up among Deepwater Horizon oil spill workers.Environmental research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegional differences in the oxidative potential of fine particulate air pollution (PM2.5) may modify its impact on the risk of myocardial infarction.
methodsA case-crossover study was conducted in 16 cities in Ontario, Canada to evaluate the impact of regional PM2.5 oxidative potential on the relationship between PM2.5 and emergency room visits for myocardial infarction. Daily air pollution and meteorological data were collected between 2004 and 2011 from provincial monitoring sites and regional estimates of glutathione (OP(GSH)) and ascorbate-related (OP(AA)) oxidative potential were determined using an acellular assay based on a synthetic respiratory tract lining fluid. Exposure variables for the combined oxidant capacity of NO2 and O3 were also examined using their sum (Ox) and a weighted average (Ox (wt)) based on their redox potentials.
resultsIn total, 30,101 cases of myocardial infarction were included in the analysis. For regions above the 90(th) percentile of OP(GSH) each 5 μg/m(3) increase in same-day PM2.5 was associated with a 7.9 % (95 % CI: 4.1, 12) increased risk of myocardial infarction whereas a 4.1 % (95 % CI: 0.26, 8.0) increase was observed in regions above the 75(th) percentile and no association was observed below the 50(th) percentile (p-interaction = 0.026). A significant 3-way interaction was detected with the strongest associations between PM2.5 and myocardial infarction occurring in areas with high regional OP(GSH) and high Ox (wt) (p-interaction < 0.001).
conclusionsRegional PM2.5 oxidative potential may modify the impact of PM2.5 on the risk of myocardial infarction. The combined oxidant capacity of NO2 and O3 may magnify this effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.