ArticleMedical decision making : an international journal of the Society for Medical Decision Making2016
Development and Evaluation of an Approach to Using Value of Information Analyses for Real-Time Prioritization Decisions Within SWOG, a Large Cancer Clinical Trials Cooperative Group.
Article in Medical decision making : an international journal of the Society for Medical Decision Making, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Are Evidence Standards Different for Genomic- vs. Clinical-Based Precision Medicine? A Quantitative Analysis of Individualized Warfarin Therapy.Clinical pharmacology and therapeutics · 2017Pooled it
- Estimating the Potential Benefits of Confirmatory Trials for Drugs with Accelerated Approval: A Comprehensive Value of Information Framework.PharmacoEconomics · 2023Trial
- Rapid Assessment of the Need for Evidence: Applying the Principles of Value of Information to Research Prioritisation.PharmacoEconomics · 2024Article
- Value of Information for Clinical Trial Design: The Importance of Considering All Relevant Comparators.PharmacoEconomics · 2024Article
- Developing and validating a multi-criteria decision analytic tool to assess the value of cancer clinical trials: evaluating cancer clinical trial value.Cost effectiveness and resource allocation : C/E · 2023Article
- Constructing Relative Effect Priors for Research Prioritization and Trial Design: A Meta-epidemiological Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2023Article
- Article
- Practical metrics for establishing the health benefits of research to support research prioritisation.BMJ global health · 2020Article
- Value of Information Analytical Methods: Report 2 of the ISPOR Value of Information Analysis Emerging Good Practices Task Force.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2020Review
- Influence of Modeling Choices on Value of Information Analysis: An Empirical Analysis from a Real-World Experiment.PharmacoEconomics · 2020Article
- How can clinical researchers quantify the value of their proposed comparative research?American heart journal · 2019Article
- Article
- Optimal Information Collection Policies in a Markov Decision Process Framework.Medical decision making : an international journal of the Society for Medical Decision Making · 2018Article
- Integrating value of research into NCI Clinical Trials Cooperative Group research review and prioritization: A pilot study.Cancer medicine · 2018Article
- Prioritizing Future Research on Allopurinol and Febuxostat for the Management of Gout: Value of Information Analysis.PharmacoEconomics · 2017Article
- Regulator Loss Functions and Hierarchical Modeling for Safety Decision Making.Medical decision making : an international journal of the Society for Medical Decision Making · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveValue of information (VOI) analyses can align research with areas with the greatest potential impact on patient outcome, but questions remain concerning the feasibility and acceptability of these approaches to inform prioritization decisions. Our objective was to develop a process for calculating VOI in "real time" to inform trial funding decisions within SWOG, a large cancer clinical trials group.
methodsWe developed an efficient and scalable VOI modeling approach using a selected sample of 9 randomized phase II/III trial proposals from the Breast, Gastrointestinal, and Genitourinary Disease Committees reviewed by SWOG's leadership between 2008 and 2013. There was bidirectional communication between SWOG investigators and the research team throughout the modeling development. Partial expected value of sample information for the treatment effect evaluated by the proposed trial's primary endpoint was calculated using Monte Carlo simulation.
resultsWe derived prior uncertainty in the treatment effect estimate from the sample size calculations. Our process was feasible for 8 of 9 trial proposals and efficient: the time required of 1 researcher was <1 week per proposal. We accommodated stakeholder input primarily by deconstructing VOI metrics into expected health benefits and incremental healthcare costs and assuming treatment decisions within our simulations were based on health benefits. Following customization, feedback from over 200 SWOG members was positive regarding the overall VOI framework, specific retrospective results, and potential for VOI analyses to inform future trial proposal evaluations.
conclusionsWe developed an efficient and customized process to calculate the expected VOI of cancer clinical trials that is feasible for use in decision making and acceptable to investigators. Prospective use and evaluation of this approach is currently underway within SWOG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.