ReviewCNS neuroscience & therapeutics2016
Neuroprotective Role of Steroidal Sex Hormones: An Overview.
Review in CNS neuroscience & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- The role of sex hormones in neurological and functional recovery following spinal cord injury in females: a systematic review of the literature.Spinal cord · 2026Pooled it
- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- Nicotine self-administration suppresses both pro- and anti-inflammatory accumbens cytokines but does not induce apoptosis in female rats.Addiction neuroscience · 2026Article
- Bypassing Androgens: Retina-Targeted 17β-Estradiol Delivery via DHED Eye Drops Ameliorates Orchiectomy-Induced Shifts in the Male Rat Visual Cortex Proteome.Antioxidants (Basel, Switzerland) · 2026Article
- Sex differences in brain glucose metabolism in alzheimer's disease: A voxel-based study.GeroScience · 2026Article
- Impact of Orchiectomy on Oxidative Stress-Induced Neurodegeneration in the Male Rat Retina: A Proteomic Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- Elevated plasma sex hormone-binding globulin (SHBG) is associated with reduced temporal lobe volume and cognitive impairment in individuals with mild cognitive impairment.European geriatric medicine · 2026Article
- The Impact of Aging and Sex on Corneal Nerve Density and Function.Investigative ophthalmology & visual science · 2026Article
- Choroidal vascularization in polycystic ovary syndrome: an optical coherence tomography study.International ophthalmology · 2026Article
- Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer's disease.Frontiers in aging neuroscience · 2026Review
- Role of paraoxonase 2 (PON2) as a potential biomarker and therapeutic target in cancer treatment.Journal of cancer research and clinical oncology · 2025Review
- Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase-Protein Kinase B-Glycogen Synthase Kinase 3β Signaling.Neuroscience · 2025Article
- Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study.BMC public health · 2025Article
- Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2025Article
- X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome.Frontiers in genetics · 2025Review
- Article
- Cognitive functioning in older transgender individuals receiving long-term gender-affirming hormone therapy.International journal of transgender health · 2025Article
- Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype.Neurochemistry international · 2024Article
- Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner.Biology of sex differences · 2024Article
- Menstrual management in transgender and gender diverse individuals: psychiatric and psychosocial considerations.Frontiers in psychiatry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone, estrogens, and testosterone are the well-known steroidal sex hormones, which have been reported to have "nonreproductive "effects in the brain, specifically in the neuroprotection and neurotrophy. In the last one decade, there has been a surge in the research on the role of these hormones in neuroprotection and their positive impact on different brain injuries. The said interest has been sparked by a desire to understand the action and mechanisms of these steroidal sex hormones throughout the body. The aim of this article was to highlight the potential outcome of the steroidal hormones, viz. progesterone, estrogens, and testosterone in terms of their role in neuroprotection and other brain injuries. Their possible mechanism of action at both genomic and nongenomic level will be also discussed. As far as our knowledge goes, we are for the first time reporting neuroprotective effect and possible mechanism of action of these hormones in a single article.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.