Evidence map›Paper›PMID 27012162›Full record

ReviewParasite (Paris, France)2016

Do advanced glycation end-products play a role in malaria susceptibility?

Karim Traoré, Charles Arama, Maurice Médebielle, Ogobara Doumbo, Stéphane Picot

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Parasite (Paris, France), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Current research in parasitology & vector-borne diseases · 2025
    Article
  2. Review
  3. Extracellular Vesicle-Contained microRNA ofFrontiers in cellular and infection microbiology · 2020
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Karim TraoréMalaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali - Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, Malaria Research Unit, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
Charles AramaMalaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.
Maurice MédebielleUniv Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
Ogobara DoumboMalaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.
Stéphane PicotUniv Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, Malaria Research Unit, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires · FRUniversité des Sciences, des Techniques et des Technologies de Bamako · MLCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are growing data supporting the differences in susceptibility to malaria described between sympatric populations with different lifestyles. Evidence has also been growing for some time that nutritional status and the host's metabolism are part of the complex mechanisms underlying these differences. The role of dietary advanced glycation end-products (AGEs) in the modulation of immune responses (innate and adaptive responses) and chronic oxidative stress has been established. But less is known about AGE implication in naturally acquired immunity and susceptibility to malaria. Since inflammatory immune responses and oxidative events have been demonstrated as the hallmark of malaria infection, it seems crucial to investigate the role of AGE in susceptibility or resistance to malaria. This review provides new insight into the relationship between nutrition, metabolic disorders, and infections, and how this may influence the mechanisms of susceptibility or resistance to malaria in endemic areas.

Indexed as

DietChromosomes, Human, Pair 6CookingDisease SusceptibilityEndemic DiseasesEthnicityEvolution, MolecularGenetic Predisposition to DiseaseGlycation End Products, AdvancedHMGB1 ProteinHost-Parasite InteractionsHumansImmunity, InnateLife StyleMajor Histocompatibility ComplexMalariaAGER protein, humanGlycation End Products, AdvancedHMGB1 ProteinHMGB1 protein, humanReceptor for Advanced Glycation End Products

Identifiers

PMID27012162
PMCPMC4807375
OpenAlexW2303714691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.