Evidence map›Paper›PMID 27011649›Full record

ArticleAnnals of Indian Academy of Neurology

Tangier's disease: An uncommon cause of facial weakness and non-length dependent demyelinating neuropathy.

Madhu Nagappa, Arun B Taly, Anita Mahadevan, M Pooja, P S Bindu, Y T Chickabasaviah, N Gayathri, Sanjib Sinha

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Madhu NagappaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Arun B TalyDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Anita MahadevanDepartment of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
M PoojaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
P S BinduDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Y T ChickabasaviahDepartment of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
N GayathriDepartment of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Sanjib SinhaDepartment of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
National Institute of Mental Health and Neurosciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tangier disease is an autosomal recessive disorder characterized by an abnormal accumulation of cholesterol esters in various organs secondary to adenotriphosphate binding cassette transporter A-1 (ABCA-1) transporter deficiency and disrupted reverse cholesterol transport. It causes neuropathy in half of the affected individuals. We present the clinical, electrophysiological, and histopathological findings in a middle aged gentleman of Tangier disease who was initially misdiagnosed leprosy and treated with antileprosy drugs. The presence of a demyelinating neuropathy on electrophysiology in a patient with predominant upper limb involvement and facial diplegia should raise the suspicion of Tangier disease. The characteristic lipid profile of Tangier disease was noted in this patient viz. extremely low high density lipoprotein (HDL), elevated triglyceride (TG), and reduced apolipoprotein A1. Estimation of serum lipids should form a part of routine evaluation in order to avoid misdiagnosis.

Indexed as

Lipid profileneuropathyTangier disease

Identifiers

PMID27011649
PMCPMC4782534
OpenAlexW2265125622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.