Evidence map›Paper›PMID 27011364›Full record

ArticleJournal of affective disorders2016

Impulsivity predicts the onset of DSM-IV-TR or RDC hypomanic and manic episodes in adolescents and young adults with high or moderate reward sensitivity.

Tommy H Ng, Jonathan P Stange, Chelsea L Black, Madison K Titone, Rachel B Weiss, Lyn Y Abramson, Lauren B Alloy

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tommy H NgDepartment of Psychology, Temple University, United States.
Jonathan P StangeDepartment of Psychology, Temple University, United States.
Chelsea L BlackDepartment of Psychology, Temple University, United States.
Madison K TitoneDepartment of Psychology, Temple University, United States.
Rachel B WeissDepartment of Psychiatry, McLean Hospital/Harvard Medical School, Unites States.
Lyn Y AbramsonDepartment of Psychology, University of Wisconsin-Madison, Unites States.
Lauren B AlloyDepartment of Psychology, Temple University, United States. Electronic address: lalloy@temple.edu.
Temple University · USMcLean Hospital · USUniversity of Wisconsin–Madison · US

Funding

Risk for Bipolar Disorder: Reward-related Brain Function & Social RhythmsR01MH077908 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2007 to 2017
$5.7M
Social and Circadian Rhythms, Reward Sensitivity, and Risk for Bipolar DisorderR01MH102310 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2014 to 2017
$1.6M
Inflexibility and Vulnerability to DepressionF31MH099761 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI STANGE, JONATHAN P · 2012 to 2014
$87k
NIMH NIH HHS F31 MH099761NIMH NIH HHS R01 MH077908NIMH NIH HHS R01 MH102310
6 · The paper itself

Abstract

backgroundA growing body of research suggests that bipolar disorders (BD) are associated with high impulsivity. Using a multi-method approach, the current study provided the first examination of the hypothesis that impulsivity would prospectively predict shorter time to onset of DSM-IV-TR or RDC hypomanic or manic episodes in a sample selected based on reward sensitivity, a biobehavioral trait shown to predict onset and course of BD.

methods163 participants with high reward sensitivity and 114 participants with moderate reward sensitivity were followed every six months for an average of 2.68 years. Participants completed the Barratt Impulsiveness Scale - Version 11 (BIS-11), Balloon Analog Risk Task (BART), Beck Depression Inventory, Altman Self-Rating Mania Scale, and an expanded Schedule for Affective Disorders and Schizophrenia (exp-SADS) - Lifetime Version at baseline and were followed prospectively with the exp-SADS - Change Version to assess onset of hypomanic or manic episodes and treatment seeking for mood problems.

resultsCox proportional hazard regression analyses indicated that impulsivity as measured by a behavioral task (BART; OR=1.04, p=.03) and a self-report measure (BIS-11 Attentional Impulsiveness subscale; OR=1.16, p=.01) predicted shorter time to hypomania/mania onset, after controlling for baseline depressive and manic symptoms, family history of mood disorder, treatment seeking for mood problems, and reward sensitivity. LIMITATIONS: The study was limited by non-comprehensive assessment of impulsivity and unknown generalizability to clinical samples.

conclusionsImpulsivity confers vulnerability to hypomania or mania. Future studies would benefit from considering how impulsivity can be integrated into existing biopsychosocial models of BD.

Indexed as

Impulsive BehaviorRewardAdolescentBipolar DisorderDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMalePsychiatric Status Rating ScalesYoung AdultBipolar disorderHypomaniaImpulsivityVulnerability

Identifiers

PMID27011364
PMCPMC4844858
OpenAlexW2300842441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.