ArticleThe journal of headache and pain2016
The efficiency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Platelet -Rich Plasma in the Therapy of Temporomandibular Disorders
Preliminary Findings of the Efficacy of Botulinum Toxin in Temporomandibular Disorders: A Randomized Clinical Trial
Comparison of the Effectiveness of Botulinum Toxin and Magnesium Sulfate Injections in the Treatment of Myofascial Trigger Points in the Masseter Muscle Randomized Controlled Clinical Trial
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- A bibliometric analysis and visualization of tension-type headache.Frontiers in neurology · 2022Pooled it
- Intramuscular Injections and Dry Needling within Masticatory Muscles in Management of Myofascial Pain. Systematic Review of Clinical Trials.International journal of environmental research and public health · 2021Pooled it
- Evidence to Use Botulinum Toxin Injections in Tension-Type Headache Management: A Systematic Review.Toxins · 2017Pooled it
- Evaluation of laser acupuncture versus physical therapy intervention in management of bruxism in children: a randomized controlled trial.BMC oral health · 2025Trial
- Influence of botulinum toxin A in pain perception and condyle-fossa relationship after the management of temporomandibular dysfunction: a randomized controlled clinical trial.Oral and maxillofacial surgery · 2024Trial
- Trial
- The Application of Manual Techniques in Masticatory Muscles Relaxation as Adjunctive Therapy in the Treatment of Temporomandibular Joint Disorders.International journal of environmental research and public health · 2021Trial
- Botulinum toxin type A and acupuncture for masticatory myofascial pain: a randomized clinical trial.Journal of applied oral science : revista FOB · 2021Trial
- Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial.Pain research & management · 2018Trial
- Assessment of the Short-Term Effectiveness of Kinesiotaping and Trigger Points Release Used in Functional Disorders of the Masticatory Muscles.Pain research & management · 2018Trial
- Post-Botulinum Headache in Cosmetic Practice: A Prospective Study.Journal of cosmetic dermatology · 2026Observational
- A Clinical Decision-Making Algorithm for Botulinum Toxin Use in Temporomandibular Disorders and Bruxism.Journal of clinical medicine · 2026Article
- Cognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity.iScience · 2025Article
- The Effective Way of Botulinum Toxin Injection to Reduce Bite Force: Preliminary Study.Toxins · 2025Article
- Assessing the Reliability of Compliance with the General Treatment Recommendations by Patients Treated for Temporomandibular Disorders.Journal of clinical medicine · 2025Article
- Review
- Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.BMC medical imaging · 2025Article
- Article
- Ultrasound-Guided Botulinum Toxin-A Injections into the Masseter Muscle for Both Medical and Aesthetic Purposes.Toxins · 2024Review
- Intra-Articular Local Anesthetics in Temporomandibular Disorders: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemporomandibular joint dysfunction are often accompanied by symptoms of headache such as tension-type headache which is the most frequent spontaneous primary headache. Masseter muscle pain is commonly reported in this group. The purpose of the study was to assess the efficiency of intramuscular botulinum toxin type A injections for treating masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache.
methodsThis prospective outcome study consisted of 42 subjects of both genders aged 19-48 years diagnosed with masseter muscle pain related to temporomandibular joint dysfunction and tension-type headache. The subjects were treated by the intramuscular injection of 21 U (mice units) of botulinum toxin type A (Botox, Allergan) in the area of the greatest cross-section surface of both masseter bellies. Pain intensity was evaluated using visual analogue scale (VAS) and verbal numerical rating scale (VNRS) 1 week before the treatment and 24 weeks after the treatment. The obtained data were analyzed using the Wilcoxon matched pairs test (p ≤ 0,005).
resultsThe results of this study showed a decrease in the number of referred pain episodes including a decrease in pain in the temporal region bilaterally, a reduction of analgesic drugs intake as well as a decrease in reported values of VAS and VNRS after injections (p = 0,000).
conclusionsThe intramuscular botulinum toxin type A injections have been an efficient method of treatment for masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.