Evidence map›Paper›PMID 27011199›Full record

ArticleViruses2016

Isolation of a Novel Fusogenic Orthoreovirus from Eucampsipoda africana Bat Flies in South Africa.

Petrus Jansen van Vuren, Michael Wiley, Gustavo Palacios, Nadia Storm, Stewart McCulloch, Wanda Markotter, Monica Birkhead, Alan Kemp, Janusz T Paweska

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 45 citations in OpenAlex.

  1. Viral Metagenomic Analysis of Bat Fly Pupae.Pathogens (Basel, Switzerland) · 2026
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  17. Vector Competence ofViruses · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Petrus Jansen van VurenCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, South Africa. petrusv@nicd.ac.za.
Michael WileyCenter for Genomic Science, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA. michael.r.wiley19.ctr@mail.mil.
Gustavo PalaciosCenter for Genomic Science, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA. gustavo.f.palacios.ctr@mail.mil.
Nadia StormCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, South Africa. nadias@nicd.ac.za.
Stewart McCullochDepartment of Microbiology and Plant Pathology, Faculty of Natural and Agricultural Science, University of Pretoria, Pretoria 0028, South Africa. Stewart.Mcculloch@up.ac.za.
Wanda MarkotterDepartment of Microbiology and Plant Pathology, Faculty of Natural and Agricultural Science, University of Pretoria, Pretoria 0028, South Africa. Wanda.Markotter@up.ac.za.
Monica BirkheadCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, South Africa. monicab@nicd.ac.za.
Alan KempCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, South Africa. alank@nicd.ac.za.
Janusz T PaweskaCentre for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham 2131, South Africa. januszp@nicd.ac.za.
National Health Laboratory Service · ZAUnited States Army Medical Research Institute of Infectious Diseases · USUniversity of Pretoria · ZA

Funding

CGH CDC HHS 5U19 GH000571-05/96667
6 · The paper itself

Abstract

We report on the isolation of a novel fusogenic orthoreovirus from bat flies (Eucampsipoda africana) associated with Egyptian fruit bats (Rousettus aegyptiacus) collected in South Africa. Complete sequences of the ten dsRNA genome segments of the virus, tentatively named Mahlapitsi virus (MAHLV), were determined. Phylogenetic analysis places this virus into a distinct clade with Baboon orthoreovirus, Bush viper reovirus and the bat-associated Broome virus. All genome segments of MAHLV contain a 5' terminal sequence (5'-GGUCA) that is unique to all currently described viruses of the genus. The smallest genome segment is bicistronic encoding for a 14 kDa protein similar to p14 membrane fusion protein of Bush viper reovirus and an 18 kDa protein similar to p16 non-structural protein of Baboon orthoreovirus. This is the first report on isolation of an orthoreovirus from an arthropod host associated with bats, and phylogenetic and sequence data suggests that MAHLV constitutes a new species within the Orthoreovirus genus.

Indexed as

Genome, ViralSequence Analysis, DNAAnimalsChiropteraCluster AnalysisDipteraMicroscopy, Electron, TransmissionMolecular WeightOrthoreovirusPhylogenyRNA, ViralSequence HomologySequence Homology, Amino AcidSouth AfricaViral ProteinsVirionRNA, ViralViral Proteinsbat fliesEucampsipoda africanafusogenic orthoreovirusNycteribiidaeReoviridaeRousettus aegyptiacus

Identifiers

PMID27011199
PMCPMC4810255
OpenAlexW2299590369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.