Evidence map›Paper›PMID 27011177›Full record

Trial reportInternational journal of molecular sciences2016

Transcranial Magnetic Stimulation of the Supplementary Motor Area in the Treatment of Obsessive-Compulsive Disorder: A Multi-Site Study.

Emily R Hawken, Dancho Dilkov, Emil Kaludiev, Selcuk Simek, Felicia Zhang, Roumen Milev

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00616486 (A Multicentre, Double-blind, Randomized, Placebo-controlled Study Evaluating the Efficacy, Safety, and Clinical Outcomes of Low Frequency, Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 40 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 8 pooled it
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00616486 nacompletednot on this map

A Multicentre, Double-blind, Randomized, Placebo-controlled Study Evaluating the Efficacy, Safety, and Clinical Outcomes of Low Frequency, Repetitive Transcranial Magnetic Stimulation (Over Supplementary Motor Area (SMA) Applied Bilaterally and Simultaneously) Versus Sham (Placebo rTMS) Treatment for 6 Weeks, When Added to a Stable Pharmacotherapy in Subjects With Obsessive Compulsive Disorder (OCD).

TypeinterventionalSponsorQueen's UniversityRan2008 to 2012Enrolled24ConditionsObsessive Compulsive DisorderArmsrepetitive transcranial magnetic stimulation, sham (placebo)
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 8 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  6. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Emily R HawkenDepartments of Psychiatry, Queen's University, Kingston, ON K7L 4X3, Canada. erhawken@gmail.com.
Dancho DilkovDepartment of Psychiatry, Military Medical Academy, Sofia 1000, Bulgaria. ddilkov@abv.bg.
Emil KaludievDepartment of Psychiatry, Military Medical Academy, Sofia 1000, Bulgaria. ekaludiev@abv.bg.
Selcuk SimekDepartment of Psychiatry, Sincan State Hospital, Istanbul 34400, Turkey. selcuk_simsek@yahoo.com.
Felicia ZhangDepartments of Psychiatry, Queen's University, Kingston, ON K7L 4X3, Canada. f.i.zhang67@gmail.com.
Roumen MilevDepartments of Psychiatry, Queen's University, Kingston, ON K7L 4X3, Canada. roumen.milev@queensu.ca.
Queen's University · CAMilitary Medical Academy · BGSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, strategies beyond pharmacological and psychological treatments have been developed for the management of obsessive-compulsive disorder (OCD). Specifically, repetitive transcranial magnetic stimulation (rTMS) has been employed as an adjunctive treatment in cases of treatment-refractory OCD. Here, we investigate six weeks of low frequency rTMS, applied bilaterally and simultaneously over the sensory motor area, in OCD patients in a randomized, double-blind placebo-controlled clinical trial. Twenty-two participants were randomly enrolled into the treatment (ACTIVE = 10) or placebo (SHAM = 12) groups. At each of seven visits (baseline; day 1 and weeks 2, 4, and 6 of treatment; and two and six weeks after treatment) the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was administered. At the end of the six weeks of rTMS, patients in the ACTIVE group showed a clinically significant decrease in Y-BOCS scores compared to both the baseline and the SHAM group. This effect was maintained six weeks following the end of rTMS treatment. Therefore, in this sample, rTMS appeared to significantly improve the OCD symptoms of the treated patients beyond the treatment window. More studies need to be conducted to determine the generalizability of these findings and to define the duration of rTMS' clinical effect on the Y-BOCS. Clinical Trial Registration Number (NCT) at www.clinicaltrials.gov: NCT00616486.

Indexed as

Transcranial Magnetic StimulationAdolescentAdultAgedFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderSensorimotor Cortexlow-frequency rTMSsensory motor areaYale-Brown obsessive compulsive scale

Identifiers

PMID27011177
PMCPMC4813271
OpenAlexW2303727589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.