ArticleJournal of developmental and behavioral pediatrics : JDBP2016
Effects of Methylphenidate on Sleep Functioning in Children with Attention-Deficit/Hyperactivity Disorder.
Article in Journal of developmental and behavioral pediatrics : JDBP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Effect of amphetamines on blood pressure.The Cochrane database of systematic reviews · 2025Pooled it
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).The Cochrane database of systematic reviews · 2023Pooled it
- Association between sleep pattern and pharmacological treatment in children with attention deficit disorder with hyperactivity: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Pooled it
- Sleep-Associated Adverse Events During Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis.The Journal of clinical psychiatry · 2019Pooled it
- Change in Sleep Latency as a Mediator of the Effect of Physical Activity Intervention on Executive Functions Among Children with ADHD: A Secondary Analysis from a Randomized Controlled Trial.Journal of autism and developmental disorders · 2024Trial
- Analysis of Daily Sleep Diary Measures From Multilayer Extended-Release Methylphenidate (PRC-063) Studies in Children and Adults With ADHD.Journal of attention disorders · 2022Trial
- Changes in Sleep Problems Across Attention-Deficit/Hyperactivity Disorder Treatment: Findings from the Multimodal Treatment of Attention-Deficit/Hyperactivity Disorder Study.Journal of child and adolescent psychopharmacology · 2018Trial
- Randomized Controlled Crossover Trials of the Pharmacokinetics of PRC-063, a Novel Multilayer Extended-Release Formulation of Methylphenidate, in Healthy Adults.Journal of clinical psychopharmacologyTrial
- Sleep and Stroop Performance with Adjunctive Melatonin in Pharmacotherapy-stable Pediatric ADHD: A Prospective Open-label Study.Indian journal of psychological medicine · 2026Article
- Methylphenidate leads to disruptions in rest/wake patterns after discontinuation.Psychopharmacology · 2026Article
- Real-world evaluation of attention deficit hyperactivity disorder symptoms and side effects in patients prescribed serdexmethylphenidate/dexmethylphenidate or other stimulants.Frontiers in pharmacology · 2026Article
- Sleep disturbances in children and adolescents with attention-deficit/hyperactivity disorder: A narrative review.World journal of clinical pediatrics · 2025Review
- Insights from 24-hour actigraphy using functional linear modeling in children with and without ADHD.Scientific reports · 2025Article
- Predictors of Methylphenidate response in children and adolescents with ADHD: the role of sleep disturbances.European archives of psychiatry and clinical neuroscience · 2025Article
- Examining daily stimulant medication use and sleep in adolescents with ADHD.European child & adolescent psychiatry · 2024Article
- Twin study of caffeine use, ADHD, and disrupted sleep in ABCD youth.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- The impact of sleep difficulties in children with attention deficit hyperactivity disorder on the family: a thematic analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Low Doses of Melatonin to Improve Sleep in Children with ADHD: An Open-Label Trial.Children (Basel, Switzerland) · 2023Article
- Dose titration of osmotic release oral system methylphenidate in children and adolescents with attention-deficit hyperactivity disorder: a retrospective cohort study.BMC pediatrics · 2023Article
- Serdexmethylphenidate/dexmethylphenidate effects on sleep in children with attention-deficit/hyperactivity disorder.Frontiers in psychiatry · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the effects of stimulant medication on the sleep functioning of children with attention-deficit/hyperactivity disorder (ADHD) and identify predictors of sleep problems as a side effect of taking stimulant medication.
methodOne hundred sixty-three stimulant-naïve children (72% boys) aged 7 to 11 years diagnosed with ADHD (120 with ADHD predominantly inattentive type, 43 with ADHD combined type) participated in a 4-week, randomized, double-blind, placebo-controlled trial of once-daily (long-acting) methylphenidate (MPH). Parents completed weekly side-effect ratings including an item related to sleep problems.
resultsTen percent of patients had parent-rated sleep problems before the initiation of medication. Rates of parent-rated sleep problems during MPH titration generally increased with increasing MPH dose (placebo: 8%; low dose: 18%; medium dose: 15%; high dose: 25%). Differences emerged between children with (n = 16) or without (n = 147) preexisting sleep problems. Although 23% of children without preexisting sleep problems went on to have sleep problems at the highest MPH dose, only 37.5% of children with preexisting sleep problems still had sleep problems at the highest MPH dose. Lower weight and lower body mass index (BMI) were associated with increased sleep problems during MPH titration.
conclusionThis study demonstrated a general association between increased MPH dose and increased sleep problems in children with ADHD, particularly for children of lower weight/BMI. However, a substantial proportion of children with preexisting sleep difficulties no longer had sleep problems on the highest MPH dose, which may help explain mixed findings reported to date in studies examining the impact of MPH on sleep functioning in children with ADHD and suggests that MPH dose titration should not be avoided solely on the basis of a child's premorbid sleep problems. Future research is needed to replicate and extend these findings to more specific domains of sleep functioning and to identify differences between children with persistent or improved sleep functioning as a result of MPH use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.