ArticleDeutsches Arzteblatt international2016
Hospital Incidence and Mortality Rates of Sepsis.
Article in Deutsches Arzteblatt international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03977688 (Evaluating a CytoSorb Score in Septic Shock - a Retrospective Multicenter Data Analysis), which is not on this map. Cited by 169 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating a CytoSorb Score in Septic Shock - a Retrospective Multicenter Data Analysis
Who cites it
169 citing papers in PubMed, 5 syntheses or guidelines pooled it, 272 citations in OpenAlex.
- Prognostic value of NLR, SII, PCT, and PLR in sepsis and septic shock: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- [Mortality in sepsis and septic shock in Germany. Results of a systematic review and meta-analysis].Der Anaesthesist · 2021Pooled it
- Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002-2016.Critical care (London, England) · 2019Pooled it
- Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.Intensive care medicine · 2017Guideline
- Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial.Critical care (London, England) · 2022Trial
- The German Quality Network Sepsis: study protocol for the evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design.Implementation science : IS · 2018Trial
- Trial
- Association between body mass index and mortality in intensive care unit patients with sepsis: A retrospective cohort study.Scientific reports · 2026Article
- [Sepsis care in Germany: quality indicators on diagnostics and treatment of sepsis].Die Anaesthesiologie · 2026Article
- The Impact of Evaluation Strategy on Sepsis Prediction Model Performance Metrics in Intensive Care Data: Retrospective Cohort Study.Journal of medical Internet research · 2026Observational
- Feasibility of Early Assessment of Cognitive Deficits in Patients With Ventilation Sepsis: A Cross-Sectional Study.Archives of rehabilitation research and clinical translation · 2026Article
- Enhanced Epigenetic Modulation via mRNA-Encapsulated Lipid Nanoparticles Enables Targeted Anti-inflammatory Control.ACS synthetic biology · 2026Article
- Predicting ICU mortality in patients with abdominal aortic aneurysm: a nomogram based on MIMIC-IV and eICU-CRD.International journal of medical sciences · 2026Article
- [Update 2025 of the S3 guidelines: "Sepsis-Prevention, diagnosis, treatment and follow-up care" : What is new?]Die Anaesthesiologie · 2025Article
- Temporal trends in sepsis hospitalisations and mortality in Aotearoa New Zealand, 2000-2019: a population-based study.The Lancet regional health. Western Pacific · 2025Article
- Epidemiology and outcomes of septic shock in Japan: a nationwide retrospective cohort study from a medical claims database by the Japan Sepsis Alliance (JaSA) study group.Critical care (London, England) · 2025Article
- Exploring the role of palmitoylation in sepsis: mechanistic insights and future perspectives.Molecular medicine (Cambridge, Mass.) · 2025Review
- Predicting ICU Mortality Among Septic Patients Using Machine Learning Technique.Journal of clinical medicine · 2025Article
- Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol.Antibiotics (Basel, Switzerland) · 2025Article
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking.
methodsNationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence and mortality of sepsis. Cases were identified on the basis of the clinical and pathogen-based ICD-10 codes for sepsis. The statistical evaluation was standardized for age and sex and carried out separately for each age group.
resultsThe number of cases of sepsis rose by an average of 5.7% per year, from 200 535 in 2007 to 279 530 in 2013, corresponding to an increase in the adjusted in-hospital incidence from 256 to 335 cases per 100 000 persons per year. The percentage of patients with severe sepsis rose from 27% to 41%. The in-hospital mortality of sepsis fell over the same period by 2.7%, to 24.3%. In 2013, 67 849 persons died of sepsis in German hospitals (or died of another disease, but also had sepsis). The incidence was highest in the youngest and oldest age groups, and the in-hospital mortality rose nearly linearly with age from age 40 onward.
conclusionSepsis and death from sepsis are markedly more common in Germany than previously assumed, and they are on the rise. Sepsis statistics should become a standard component of federal statistical reports on public health, as well as of hospital statistics. Preventive measures and evidencebased treatment should be implemented across the nation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.