Evidence map›Paper›PMID 27010870›Full record

ArticleAIDS care2016

Side effects, adherence self-efficacy, and adherence to antiretroviral treatment: a mediation analysis in a Chinese sample.

Liying Zhang, Xiaoming Li, Zhenping Lin, Angela J Jacques-Tiura, Jinping Xu, Yuejiao Zhou, Shan Qiao, Zhiyong Shen, Bonita Stanton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Understanding How Gay, Bisexual, and Other Men Who Have Sex With Men in China Cope With HIV Care-Related Stressors.AIDS education and prevention : official publication of the International Society for AIDS Education · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liying Zhanga The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.
Xiaoming Lia The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.
Zhenping Lina The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.
Angela J Jacques-Tiuraa The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.
Jinping Xud Department of Family Medicine and Public Health Sciences , Wayne State University School of Medicine , Detroit , MI , USA.
Yuejiao Zhoue Guangxi Center for Disease Control and Prevention , Nanning , People's Republic of China.
Shan Qiaoa The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.
Zhiyong Shene Guangxi Center for Disease Control and Prevention , Nanning , People's Republic of China.
Bonita Stantona The Carman and Ann Adams Department of Pediatrics , Wayne State University School of Medicine , Detroit , MI , USA.

Funding

Venue-based HIV and alcohol use risk reduction among female sex workers in ChinaR01AA018090 · NIAAA · WAYNE STATE UNIVERSITY · PI LI, XIAOMING · 2008 to 2012
$2.6M
Theory-based HIV Disclosure Intervention for ParentsR01HD074221 · NICHD · WAYNE STATE UNIVERSITY · PI LI, XIAOMING · 2012 to 2017
$1.7M
NIAAA NIH HHS R01 AA018090NICHD NIH HHS R01 HD074221
6 · The paper itself

Abstract

Antiretroviral therapy (ART) is a lifelong treatment. To date, ART adherence is suboptimal for most patients in resource-poor settings. Previous research indicates that medication side effects are perceived to be a significant barrier of high ART adherence. Data regarding the role of adherence self-efficacy in mediating the relationship between side effects from ART and adherence to ART are limited; thus, this study examines this potential mediational role of self-efficacy. A cross-sectional survey of 2987 people living with HIV aged ≥18 years was conducted in 2012-2013 in Guangxi Autonomous Region (Guangxi) which has one of the fastest-growing HIV rates in China. Of the total sample, 2146 (72.1%) participants had initiated ART. Participants reported the number of days of completing the daily dose of ART in the past month; adherence was defined as completing the daily dose at least 28 days in the last month (≥90%). Side effects were significantly negatively related to adherence to ART. Mediation analyses indicated that adherence self-efficacy significantly mediated the side effects-adherence relationship. Future interventions to increase adherence self-efficacy and effective coping with side effects among HIV patients are needed in order to improve their ART adherence.

Indexed as

Antiretroviral Therapy, Highly ActiveHIV InfectionsAdaptation, PsychologicalAdolescentAdultChinaCross-Sectional StudiesDrug MonitoringDrug-Related Side Effects and Adverse ReactionsFemaleHumansMaleMedication AdherenceMiddle AgedNeeds AssessmentSelf EfficacyAdherenceadherence self-efficacyantiretroviral therapy (ART)ChinaHIV infectionside effects

Identifiers

PMID27010870
PMCPMC6065505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.