Trial reportBirth defects research. Part A, Clinical and molecular teratology2016
Red Blood Cell Folate Insufficiency among nonpregnant Women of Childbearing age in Guatemala 2009 to 2010: Prevalence and predicted Neural Tube Defects risk.
Trial report in Birth defects research. Part A, Clinical and molecular teratology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues.Annals of the New York Academy of Sciences · 2018Pooled it
- Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation.The American journal of clinical nutrition · 2019Trial
- Beyond Calories: Addressing Micronutrient Deficiencies in the World's Most Vulnerable Communities-A Review.Nutrients · 2025Review
- Folate and Vitamin B12 Status among Non-Pregnant, Non-Lactating Women of Reproductive Age and Predicted Risk for Neural Tube Defects, Morogoro Region, Tanzania.Maternal and child health journal · 2025Article
- A Multilevel Analysis of the Association Between Quality of Antenatal Care and Folic Acid Supplementation During Pregnancy Among Guatemalan Women.Global health, epidemiology and genomics · 2025Article
- Secondary Analysis Assesses Dietary Diversity Changes among Maya Guatemalan Women Post-Nutrition Interventions.Maternal and child health journal · 2024Article
- Folate and Vitamin B12 Status in Women of Reproductive Age in Rural Haryana, India: Estimating Population-Based Prevalence for Neural Tube Defects.Birth defects research · 2024Article
- Folate and vitamin BBirth defects research · 2024Article
- Micronutrient deficiencies and their co-occurrence among pregnant women in Mbeya region, Tanzania.PloS one · 2024Article
- Neural tube defects: a review of global prevalence, causes, and primary prevention.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Intake of Vitamin B12 and Folate and Biomarkers of Nutrient Status of Women within Two Years Postpartum.Nutrients · 2022Article
- Anemia and Vitamin B-12 and Folate Status in Women of Reproductive Age in Southern India: Estimating Population-Based Risk of Neural Tube Defects.Current developments in nutrition · 2021Article
- Folate status in the US population 20 y after the introduction of folic acid fortification.The American journal of clinical nutrition · 2019Article
- Folate of pregnant women after a nationwide folic acid supplementation in China.Maternal & child nutrition · 2019Article
- Triple surveillance: a proposal for an integrated strategy to support and accelerate birth defect prevention.Annals of the New York Academy of Sciences · 2018Article
- Folate Deficiency Is Prevalent in Women of Childbearing Age in Belize and Is Negatively Affected by Coexisting Vitamin B-12 Deficiency: Belize National Micronutrient Survey 2011.The Journal of nutrition · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe World Health Organization recently released recommendations stating that red blood cell (RBC) folate concentrations should be above 400 ng/L (906 nmol/L) for optimal prevention of folate-sensitive neural tube defects (NTDs). The objective of this study was to determine the distribution of folate insufficiency (FI) (<906 nmol/L) and potential risk of NTDs based on RBC folate concentrations among nonpregnant women of child-bearing age in Guatemala.
methodsA national and regional multistage cluster probability survey was completed during 2009 to 2010 among Guatemalan women of child-bearing age 15 to 49 years of age. Demographic and health information and blood samples for RBC folate analyses were collected from 1473 women. Prevalence rate ratios of FI and predicted NTD prevalence were estimated based on RBC folate concentrations comparing subpopulations of interest.
resultsNational FI prevalence was 47.2% [95% confidence interval, 43.3-51.1] and showed wide variation by region (18-81%). In all regions, FI prevalence was higher among indigenous (27-89%) than among nonindigenous populations (16-44%). National NTD risk based on RBC folate concentrations was estimated to be 14 per 10,000 live births (95% uncertainty interval, 11.1-18.6) and showed wide regional variation (from 11 NTDS in the Metropolitan region to 26 NTDs per 10,000 live births in the Norte region).
conclusionFI remains a common problem in populations with limited access to fortified products, specifically rural, low income, and indigenous populations. However, among subpopulations that are most likely to have fortified food, the prevalence of FI is similar to countries with well-established fortification programs. Birth Defects Research (Part A) 106:587-595, 2016. © 2016 Wiley Periodicals, Inc.
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