ArticlePLoS computational biology2016
Cellular Growth Arrest and Persistence from Enzyme Saturation.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
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- A Reduction of Transcriptional Regulation in Aquatic Oligotrophic Microorganisms Enhances Fitness in Nutrient-Poor Environments.Microbiology and molecular biology reviews : MMBR · 2023Review
- Kinetics, Thermodynamics and Mechanism of Enzymatic Degradation of Zearalenone in Degummed Corn Oil.Toxins · 2022Article
- Removal of Zearalenone from Degummed Corn Oil by Hydrolase on a Batch-Refining Unit.Foods (Basel, Switzerland) · 2022Article
- Gene regulation by a protein translation factor at the single-cell level.PLoS computational biology · 2022Article
- Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis.Nature communications · 2022Article
- Antibiotic tolerance in environmentally stressedmicroLife · 2022Article
- SAR11 Cells Rely on Enzyme Multifunctionality To Metabolize a Range of Polyamine Compounds.mBio · 2021Article
- Pareto optimality between growth-rate and lag-time couples metabolic noise to phenotypic heterogeneity in Escherichia coli.Nature communications · 2021Article
- Emergent Damped Oscillation Induced by Nutrient-Modulating Growth Feedback.ACS synthetic biology · 2021Article
- How Do Cells Adapt? Stories Told in Landscapes.Annual review of chemical and biomolecular engineering · 2020Review
- Diversity inmBio · 2019Article
- Synchronization of stochastic expressions drives the clustering of functionally related genes.Science advances · 2019Article
- Power-law tail in lag time distribution underlies bacterial persistence.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Noise propagation in an integrated model of bacterial gene expression and growth.PLoS computational biology · 2018Article
- Lineage space and the propensity of bacterial cells to undergo growth transitions.PLoS computational biology · 2018Article
- Late-Arriving Signals Contribute Less to Cell-Fate Decisions.Biophysical journal · 2017Article
- Dynamical predictors of an imminent phenotypic switch in bacteria.Physical biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Metabolic efficiency depends on the balance between supply and demand of metabolites, which is sensitive to environmental and physiological fluctuations, or noise, causing shortages or surpluses in the metabolic pipeline. How cells can reliably optimize biomass production in the presence of metabolic fluctuations is a fundamental question that has not been fully answered. Here we use mathematical models to predict that enzyme saturation creates distinct regimes of cellular growth, including a phase of growth arrest resulting from toxicity of the metabolic process. Noise can drive entry of single cells into growth arrest while a fast-growing majority sustains the population. We confirmed these predictions by measuring the growth dynamics of Escherichia coli utilizing lactose as a sole carbon source. The predicted heterogeneous growth emerged at high lactose concentrations, and was associated with cell death and production of antibiotic-tolerant persister cells. These results suggest how metabolic networks may balance costs and benefits, with important implications for drug tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.