Evidence map›Paper›PMID 27010388›Full record

ArticlePloS one2016

Comparative Screening of Digestion Tract Toxic Genes in Proteus mirabilis.

Xiaolu Shi, Yiman Lin, Yaqun Qiu, Yinghui Li, Min Jiang, Qiongcheng Chen, Yixiang Jiang, Jianhui Yuan, Hong Cao, Qinghua Hu and 1 more

Abstract readComparative Study
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Description on the prevalence ofFrontiers in microbiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Draft Genome ofFrontiers in cellular and infection microbiology · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Proteus spp. as Putative Gastrointestinal Pathogens.Clinical microbiology reviews · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaolu ShiSchool of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.
Yiman LinShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Yaqun QiuShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Yinghui LiShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Min JiangShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Qiongcheng ChenShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Yixiang JiangShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Jianhui YuanShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Hong CaoSchool of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.
Qinghua HuShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Shenghe HuangSchool of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteus mirabilis is a common urinary tract pathogen, and may induce various inflammation symptoms. Its notorious ability to resist multiple antibiotics and to form urinary tract stones makes its treatment a long and painful process, which is further challenged by the frequent horizontal gene transferring events in P. mirabilis genomes. Three strains of P. mirabilis C02011/C04010/C04013 were isolated from a local outbreak of a food poisoning event in Shenzhen, China. Our hypothesis is that new genes may have been acquired horizontally to exert the digestion tract infection and toxicity. The functional characterization of these three genomes shows that each of them independently acquired dozens of virulent genes horizontally from the other microbial genomes. The representative strain C02011 induces the symptoms of both vomit and diarrhea, and has recently acquired a complete type IV secretion system and digestion tract toxic genes from the other bacteria.

Indexed as

ChinaFoodborne DiseasesGenes, BacterialHumansPhylogenyProteus InfectionsProteus mirabilis

Identifiers

PMID27010388
PMCPMC4807080

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.