ArticleAngewandte Chemie (International ed. in English)2016
Daisy Chain Rotaxanes Made from Interlocked DNA Nanostructures.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interlocked DNA Nanojoints for Reversible Thermal Sensing.Angewandte Chemie (International ed. in English) · 2020Article
- Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures.Nature protocols · 2019Article
- Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation.Nucleic acids research · 2018Article
- A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks.Nature nanotechnology · 2018Article
- DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching.Angewandte Chemie (International ed. in English) · 2016Article
- Long-range movement of large mechanically interlocked DNA nanostructures.Nature communications · 2016Article
- Daisy Chain Rotaxanes Made from Interlocked DNA Nanostructures.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report the stepwise assembly of supramolecular daisy chain rotaxanes (DCR) made of double-stranded DNA: Small dsDNA macrocycles bearing an axle assemble into a pseudo-DCR precursor that was connected to rigid DNA stoppers to form DCR with the macrocycles hybridized to the axles. In presence of release oligodeoxynucleotides (rODNs), the macrocycles are released from their respective hybridization sites on the axles, leading to stable mechanically interlocked DCRs. Besides the expected threaded DCRs, certain amounts of externally hybridized structures were observed, which dissociate into dumbbell structures in presence of rODNs. We show that the genuine DCRs have significantly higher degrees of freedom in their movement along the thread axle than the hybridized DCR precursors. Interlocking of DNA in DCRs might serve as a versatile principle for constructing functional DNA nanostructures where the movement of the subunits is restricted within precisely confined tolerance ranges.
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Registered trials
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