ArticleOncotarget2016
Preoperative serum fibrinogen is an independent prognostic factor in operable esophageal cancer.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Preoperative plasma fibrinogen is associated with poor prognosis in esophageal carcinoma: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Pooled it
- Markers of Inflammation and Incident Breast Cancer Risk in the Women's Health Study.American journal of epidemiology · 2018Trial
- The role of ADAM8 in the mechanophenotype of MDA-MB-231 breast cancer cells in 3D extracellular matrices.Frontiers in cell and developmental biology · 2023Article
- The Prognostic Value of Combination of Plasma Fibrinogen and CA19-9 in Non-Distant Metastatic Breast Cancer Patients Undergoing Surgery.Cancer management and research · 2020Article
- Preoperative weight loss is associated with poorer prognosis in operable esophageal cancer patients: A single-center retrospective analysis of a large cohort of Chinese patients.Journal of Cancer · 2020Article
- Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study.Cancer management and research · 2019Article
- Variability of serum novel serum peptide biomarkers correlates with the disease states of multiple myeloma.Clinical proteomics · 2019Article
- Prognostic significance of combined preoperative fibrinogen and CA199 in gallbladder cancer patients.World journal of gastroenterology · 2018Article
- Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma.BMC cancer · 2018Article
- Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma.International journal of molecular sciences · 2018Article
- The association of plasma fibrinogen with clinicopathological features and prognosis in esophageal cancer patients.Oncotarget · 2017Article
- Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma.International journal of clinical oncology · 2017Article
- Low Preoperative albumin-to-globulin ratio Predict Poor Survival and Negatively Correlated with Fibrinogen in Resectable Esophageal Squamous Cell Carcinoma.Journal of Cancer · 2017Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to fully elucidate the association between serum fibrinogen and prognosis of esophageal cancer, we examined serum fibrinogen concentrations in 1512 patients who underwent esophagectomy by the Clauss method. The impact of fibrinogen on overall survival and disease-free survival was analyzed using the Kaplan-Meier method and Cox proportional hazard models. Hyperfibrinogenemia was significantly associated with older age, male gender, smoking, alcohol consumption, weight loss, advanced pathological T stage and lymph node metastasis. Patients with hyperfibrinogenemia exhibited poor OS (HR=1.20, 95%CI: 1.04-1.38, P=0.012) and DFS (HR=1.18, 95%CI: 1.03-1.35, P=0.019). Subgroup analysis further exhibited an significant association between hyperfibrinogenemia and poor OS (P<0.001), DFS (P<0.001) in esophageal squamous cell carcinoma (P<0.001) and early pathological stage (I-II) (P=0.001). Collectively, this study indicates that preoperative serum fibrinogen is an independent prognostic factor for survival in esophageal cancer.
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