ArticleDatabase : the journal of biological databases and curation2016
The Disease Portals, disease-gene annotation and the RGD disease ontology at the Rat Genome Database.
Article in Database : the journal of biological databases and curation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Mapping of EFO terms from the GWAS catalog data to multiple ontologies at the Rat Genome Database.Database : the journal of biological databases and curation · 2026Article
- Identification of key genes for fish adaptation to freshwater and seawater based on attention mechanism.BMC genomics · 2025Article
- Standardized pipelines support and facilitate integration of diverse datasets at the Rat Genome Database.Database : the journal of biological databases and curation · 2025Article
- Rare disease research resources at the Rat Genome Database.Genetics · 2023Article
- 2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource.Genetics · 2023Article
- Ontological Analysis of Coronavirus Associated Human Genes at the COVID-19 Disease Portal.Genes · 2022Article
- TCRD and Pharos 2021: mining the human proteome for disease biology.Nucleic acids research · 2021Article
- Bioinformatic Analysis Combined With Experimental Validation Reveals Novel Hub Genes and Pathways Associated With Focal Segmental Glomerulosclerosis.Frontiers in molecular biosciences · 2021Article
- Rat Models of Metabolic Syndrome.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Integrated curation and data mining for disease and phenotype models at the Rat Genome Database.Database : the journal of biological databases and curation · 2019Article
- Disease Ontology: improving and unifying disease annotations across species.Disease models & mechanisms · 2018Article
- Knowledge Representation and Management, It's Time to Integrate!Yearbook of medical informatics · 2017Review
- Identifying genes for neurobehavioural traits in rodents: progress and pitfalls.Disease models & mechanisms · 2017Review
- The Comparative Toxicogenomics Database: update 2017.Nucleic acids research · 2017Article
- Exploring human disease using the Rat Genome Database.Disease models & mechanisms · 2016Review
- Comprehensive coverage of cardiovascular disease data in the disease portals at the Rat Genome Database.Physiological genomics · 2016Article
- The Chinchilla Research Resource Database: resource for an otolaryngology disease model.Database : the journal of biological databases and curation · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
The Rat Genome Database (RGD;http://rgd.mcw.edu/) provides critical datasets and software tools to a diverse community of rat and non-rat researchers worldwide. To meet the needs of the many users whose research is disease oriented, RGD has created a series of Disease Portals and has prioritized its curation efforts on the datasets important to understanding the mechanisms of various diseases. Gene-disease relationships for three species, rat, human and mouse, are annotated to capture biomarkers, genetic associations, molecular mechanisms and therapeutic targets. To generate gene-disease annotations more effectively and in greater detail, RGD initially adopted the MEDIC disease vocabulary from the Comparative Toxicogenomics Database and adapted it for use by expanding this framework with the addition of over 1000 terms to create the RGD Disease Ontology (RDO). The RDO provides the foundation for, at present, 10 comprehensive disease area-related dataset and analysis platforms at RGD, the Disease Portals. Two major disease areas are the focus of data acquisition and curation efforts each year, leading to the release of the related Disease Portals. Collaborative efforts to realize a more robust disease ontology are underway. Database URL:http://rgd.mcw.edu.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.