ArticleScientific reports2016
A model to assess the efficacy of vaccines for control of liver fluke infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Human fascioliasis in Africa: A systematic review.PloS one · 2021Pooled it
- Construction and Immunogenicity Evaluation of a Digestive Protein-Based Chimeric Antigen Composed of Cathepsin L1, Cathepsin B1, and Saposin-like Protein 2 fromInternational journal of molecular sciences · 2026Article
- Molecular identification ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Article
- In silico design of an epitope-based vaccine ensemble for fasliolopsiasis.Frontiers in genetics · 2024Article
- Fasciola spp. in Southeast Asia: a systematic review and meta-analysis protocol.Systematic reviews · 2022Article
- Co-Administration of Adjuvanted RecombinantVaccines · 2022Article
- Exploration of factors associated with spatial-temporal veterinary surveillance diagnoses of rumen fluke (Parasitology · 2022Article
- Review
- What Modeling Parasites, Transmission, and Resistance Can Teach Us.The Veterinary clinics of North America. Food animal practice · 2020Review
- Helminth Vaccines in Ruminants: From Development to Application.The Veterinary clinics of North America. Food animal practice · 2020Review
- Refugia and anthelmintic resistance: Concepts and challenges.International journal for parasitology. Drugs and drug resistance · 2019Review
- A mechanistic hydro-epidemiological model of liver fluke risk.Journal of the Royal Society, Interface · 2018Article
- Fasciola and fasciolosis in ruminants in Europe: Identifying research needs.Transboundary and emerging diseases · 2018Review
- Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation.Infection and immunity · 2018Article
- Structure-based modelling of hemocyanin allergenicity in squid and its response to high hydrostatic pressure.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Fasciola hepatica, common liver fluke, infects cattle and sheep causing disease and production losses costing approximately $3 billion annually. Current control relies on drugs designed to kill the parasite. However, resistance is evident worldwide and widespread in some areas. Work towards a vaccine has identified several antigens of F. hepatica that show partial efficacy in terms of reducing worm burden and egg output. A critical question is what level of efficacy is required for such a vaccine to be useful? We have created the first mathematical model to assess the effectiveness of liver fluke vaccines under simulated field conditions. The model describes development of fluke within a group of animals and includes heterogeneity in host susceptibility, seasonal exposure to metacercariae and seasonal changes in temperature affecting metacercarial survival. Our analysis suggests that the potential vaccine candidates could reduce total fluke burden and egg output by up to 43% and 99%, respectively, on average under field conditions. It also suggests that for a vaccine to be effective, it must protect at least 90% of animals for the whole season. In conclusion, novel, partial, vaccines could contribute substantially towards fasciolosis control, reducing usage of anthelmintics and thus delaying the spread of anthelmintic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.