ArticleJournal of biophotonics2017
Non-invasive optical assessment of viscosity of middle ear effusions in otitis media.
Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Quantitative Pneumatic Otoscopy Using a Light-Based Ranging Technique.Journal of the Association for Research in Otolaryngology : JARO · 2017Trial
- Optical Coherence Tomography as an Emerging Technique for Identifying Pediatric Middle Ear Effusion.The Laryngoscope · 2026Article
- Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects.Journal of biomedical optics · 2025Article
- Optical Coherence Tomography Imaging and Angiography of Skull Base Tumors Presenting as a Middle Ear Mass in Clinic.Diagnostics (Basel, Switzerland) · 2025Article
- AMP-Coated TiOInternational journal of nanomedicine · 2024Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections.Biosensors · 2021Article
- Investigations on the potential of optical coherence tomography as an imaging tool for eustachian tube.Scientific reports · 2021Article
- Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy.Scientific reports · 2021Article
- Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2020Article
- Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020Review
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- In vivo detection of endotracheal tube biofilms in intubated critical care patients using catheter-based optical coherence tomography.Journal of biophotonics · 2019Article
- In Vivo Vibration Measurement of Middle Ear Structure Using Doppler Optical Coherence Tomography: Preliminary Study.Clinical and experimental otorhinolaryngology · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane.Journal of biomedical optics · 2018Article
- Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography.Biomedical optics express · 2018Article
- Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications.Journal of biomedical optics · 2018Article
- Direct Analysis of Pathogenic Structures Affixed to the Tympanic Membrane during Chronic Otitis Media.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018Article
- In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity and form a middle ear effusion (MEE). MEEs can persist for weeks or months and cause hearing loss as well as speech and learning delays in young children. The ability of a physician to accurately identify and characterize the middle ear for signs of fluid and/or infection is crucial to provide the most appropriate treatment for the patient. Currently, middle ear infections are assessed with otoscopy, which provides limited and only qualitative diagnostic information. In this study, we propose a method utilizing cross-sectional depth-resolved optical coherence tomography to noninvasively measure the diffusion coefficient and viscosity of colloid suspensions, such as a MEE. Experimental validation of the proposed technique on simulated MEE phantoms with varying viscosity and particulate characteristics is presented, along with some preliminary results from in vivo and ex vivo samples of human MEEs. In vivo Optical Coherence Tomography (OCT) image of a human tympanic membrane and Middle Ear Effusion (MEE) (top), with a CCD image of the tympanic membrane surface (inset). Below is the corresponding time-lapse M-mode OCT data acquired along the white dotted line over time, which can be analyzed to determine the Stokes-Einstein diffusion coefficient of the effusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.