ArticleAddiction (Abingdon, England)2016
Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states.
Article in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Targeting women veteran's stress-induced drinking with cognitive reappraisal: Mechanisms and moderators of change.Journal of substance abuse treatment · 2021Trial
- Moderators of sudden gains after sessions addressing emotion regulation among women in treatment for alcohol use.Journal of substance abuse treatment · 2017Trial
- Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- (R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats.Psychopharmacology · 2026Article
- Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.medRxiv : the preprint server for health sciences · 2025Article
- The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.Addiction neuroscience · 2025Article
- Associations of plasma sex-related hormone and protein levels and alcohol dependence.Addiction (Abingdon, England) · 2025Article
- Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice.Scientific reports · 2024Article
- Correlates and consequences of anxiety and depressive symptom trajectories during early treatment for alcohol use.Alcohol (Fayetteville, N.Y.) · 2023Article
- Inpatients in substance use treatment with co-occurring psychiatric disorders: a prospective cohort study of characteristics and relapse predictors.BMC psychiatry · 2023Article
- Self-compassion buffers the internalized alcohol stigma and depression link in women sexual assault survivors who drink to cope.Addictive behaviors · 2023Article
- Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder.Drug and alcohol dependence · 2023Article
- Alcohol use and motives for drinking across the menstrual cycle in a psychiatric outpatient sample.Alcohol, clinical & experimental research · 2023Article
- Transgender individuals are at higher risk for suicidal ideation and preparation than cisgender individuals in substance use treatment.Frontiers in psychiatry · 2023Article
- Longitudinal co-trajectories of depression and alcohol problems in adults during the COVID-19 pandemic.Current psychology (New Brunswick, N.J.) · 2022Article
- Relationship between Alcohol Intake and Chronic Pain with Depressive Symptoms: A Cross-Sectional Analysis of the Shika Study.International journal of environmental research and public health · 2022Article
- The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats.Frontiers in behavioral neuroscience · 2022Article
- Pilot examination of stress, heart rate variability, and alcohol craving and use among female veterans.Frontiers in psychiatry · 2022Article
- Understanding low treatment seeking rates for alcohol use disorder: A narrative review of the literature and opportunities for improvement.The American journal of drug and alcohol abuse · 2021Review
- Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication.AIMS neuroscience · 2021Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsDepression and anxiety are often comorbid with alcoholism and contribute to craving and relapse. We aimed to estimate the prevalence of life-time diagnoses of major depressive disorder (MDD), substance-induced depression (SID), anxiety disorder (AnxD) and substance-induced anxiety (SIA), the effects of these comorbidities on the propensity to drink in negative emotional states (negative craving), and test whether these effects differ by sex.
designSecondary analyses of baseline data collected in a single-arm study of pharmacogenetic predictors of acamprosate response.
settingAcademic medical center and affiliated community-based treatment programs in the American upper mid-west.
participantsA total of 287 males and 156 females aged 18-80 years, meeting DSM-IV criteria for alcohol dependence. MEASUREMENTS: The primary outcome measure was 'propensity to drink in negative emotional situations' (determined by the Inventory of Drug Taking Situations) and the key predictors/covariates were sex and psychiatric comorbidities, including MDD, SID, AnxD and SIA (determined by Psychiatric Research Interview of Substance and Mood Disorders).
findingsThe prevalence of the MDD, SID and AnxD was higher in females compared with males (33.1 versus 18.4%, 44.8 versus 26.4% and 42.2 versus 27.4%, respectively; P < 0.01, each), while SIA was rare (3.3%) and did not differ by sex. Increased propensity to drink in negative emotional situations was associated with comorbid MDD (β = 6.6, P = 0.013) and AnxD (β = 4.8, P = 0.042) as well as a SID × sex interaction effect (P = 0.003), indicating that the association of SID with propensity to drink in negative emotional situations differs by sex and is stronger in males (β = 7.9, P = 0.009) compared with females (β = -6.6, P = 0.091).
conclusionsThere appears to be a higher prevalence of comorbid depression and anxiety disorders as well as propensity to drink in negative emotional situations in female compared with male alcoholics. Substance-induced depression appears to have a sex-specific effect on the increased risk for drinking in negative emotional situations in males.
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