ArticleScientific reports2016
Amyloid-like ribbons of amelogenins in enamel mineralization.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- Serine-16 Phosphorylation, C-Terminal Truncation, and Ion-Specific Interactions Coordinate Amelogenin Nanoribbon Formation.Calcified tissue international · 2026Article
- Amelogenin proteolysis orchestrates functional amyloid pathways in enamel development.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair.Frontiers in bioengineering and biotechnology · 2026Article
- Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel.Nature communications · 2025Article
- Effect of Recombinant Human Amelogenin on the Osteogenic Differentiation Potential of SHED.Cells · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- SAXS of murine amelogenin identifies a persistent dimeric species from pH 5.0 to 8.0.Journal of structural biology · 2024Article
- Recombinant human enamelin produced in Escherichia coli promotes mineralization in vitro.BMC biotechnology · 2024Article
- Accurate informatic modeling of tooth enamel pellicle interactions by training substitution matrices with Mat4Pep.Frontiers in materials · 2024Article
- Biomimetic Mineral Synthesis by Nanopatterned Supramolecular-Block Copolymer Templates.Nano letters · 2023Article
- High-yield recombinant bacterial expression ofProtein science : a publication of the Protein Society · 2023Article
- Residue-Specific Insights into the Intermolecular Protein-Protein Interfaces Driving Amelogenin Self-Assembly in Solution.Biochemistry · 2022Article
- The power of weak ion-exchange resins assisted by amelogenin for natural remineralization of dental enamel: an in vitro study.Odontology · 2022Article
- Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Calcium interactions in amelogenin-derived peptide assembly.Frontiers in physiology · 2022Article
- Advanced materials for enamel remineralization.Frontiers in bioengineering and biotechnology · 2022Review
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Amelogenesis: Transformation of a protein-mineral matrix into tooth enamel.Journal of structural biology · 2021Review
- A Brief History of the Discovery of Amelogenin Nanoribbons In Vitro and In Vivo.Journal of dental research · 2021Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Enamel, the outermost layer of teeth, is an acellular mineralized tissue that cannot regenerate; the mature tissue is composed of high aspect ratio apatite nanocrystals organized into rods and inter-rod regions. Amelogenin constitutes 90% of the protein matrix in developing enamel and plays a central role in guiding the hierarchical organization of apatite crystals observed in mature enamel. To date, a convincing link between amelogenin supramolecular structures and mature enamel has yet to be described, in part because the protein matrix is degraded during tissue maturation. Here we show compelling evidence that amelogenin self-assembles into an amyloid-like structure in vitro and in vivo. We show that enamel matrices stain positive for amyloids and we identify a specific region within amelogenin that self-assembles into β-sheets. We propose that amelogenin nanoribbons template the growth of apatite mineral in human enamel. This is a paradigm shift from the current model of enamel development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.