ArticleJournal of neurophysiology2016
Predicting binaural responses from monaural responses in the gerbil medial superior olive.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Specific loss of neural sensitivity to interaural time difference of unmodulated noise stimuli following noise-induced hearing loss.Journal of neurophysiology · 2020Article
- Cortical mechanisms of spatial hearing.Nature reviews. Neuroscience · 2019Review
- Precisely timed inhibition facilitates action potential firing for spatial coding in the auditory brainstem.Nature communications · 2018Article
- Signatures of Somatic Inhibition and Dendritic Excitation in Auditory Brainstem Field Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Enhancement of phase-locking in rodents. I. An axonal recording study in gerbil.Journal of neurophysiology · 2017Article
- A Test of the Stereausis Hypothesis for Sound Localization in Mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The organization of frequency and binaural cues in the gerbil inferior colliculus.The Journal of comparative neurology · 2017Article
- Amplitude Normalization of Dendritic EPSPs at the Soma of Binaural Coincidence Detector Neurons of the Medial Superior Olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Exploring binaural hearing in gerbils (Meriones unguiculatus) using virtual headphones.PloS one · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate sound source localization of low-frequency sounds in the horizontal plane depends critically on the comparison of arrival times at both ears. A specialized brainstem circuit containing the principal neurons of the medial superior olive (MSO) is dedicated to this comparison. MSO neurons are innervated by segregated inputs from both ears. The coincident arrival of excitatory inputs from both ears is thought to trigger action potentials, with differences in internal delays creating a unique sensitivity to interaural time differences (ITDs) for each cell. How the inputs from both ears are integrated by the MSO neurons is still debated. Using juxtacellular recordings, we tested to what extent MSO neurons from anesthetized Mongolian gerbils function as simple cross-correlators of their bilateral inputs. From the measured subthreshold responses to monaural wideband stimuli we predicted the rate-ITD functions obtained from the same MSO neuron, which have a damped oscillatory shape. The rate of the oscillations and the position of the peaks and troughs were accurately predicted. The amplitude ratio between dominant and secondary peaks of the rate-ITD function, captured in the width of its envelope, was not always exactly reproduced. This minor imperfection pointed to the methodological limitation of using a linear representation of the monaural inputs, which disregards any temporal sharpening occurring in the cochlear nucleus. The successful prediction of the major aspects of rate-ITD curves supports a simple scheme in which the ITD sensitivity of MSO neurons is realized by the coincidence detection of excitatory monaural inputs.
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