Evidence map›Paper›PMID 27009100›Full record

ArticleGenome biology2016

The real cost of sequencing: scaling computation to keep pace with data generation.

Paul Muir, Shantao Li, Shaoke Lou, Daifeng Wang, Daniel J Spakowicz, Leonidas Salichos, Jing Zhang, George M Weinstock, Farren Isaacs, Joel Rozowsky and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 152 papers.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed.

  1. Review
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  17. Genomic selection for crop improvement in fruits and vegetables: a systematic scoping review.Molecular breeding : new strategies in plant improvement · 2024
    Article
  18. Article
  19. Article
  20. Article

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Paul MuirDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA.
Shantao LiProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Shaoke LouProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Daifeng WangProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Daniel J SpakowiczProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Leonidas SalichosProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Jing ZhangProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
George M WeinstockThe Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Farren IsaacsDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 06520, USA.
Joel RozowskyProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA.
Mark GersteinProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06520, USA. mark@gersteinlab.org.

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
MEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2M
EDAC: ENCODE Data Analysis CenterU41HG007000 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WENG, ZHIPING · 2012 to 2016
$9.8M
NHGRI NIH HHS U41 HG007000NHGRI NIH HHS U41 HG007000-03
6 · The paper itself

Abstract

As the cost of sequencing continues to decrease and the amount of sequence data generated grows, new paradigms for data storage and analysis are increasingly important. The relative scaling behavior of these evolving technologies will impact genomics research moving forward.

Indexed as

AlgorithmsBiomedical ResearchComputational BiologyGenomicsHigh-Throughput Nucleotide SequencingHumansInformation Storage and Retrieval

Identifiers

PMID27009100
PMCPMC4806511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.