ArticleJournal of clinical microbiology2016
One Small Step for the Gram Stain, One Giant Leap for Clinical Microbiology.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Lipopolysaccharide-Specific Aptasensor: A Spectroscopic Approach for Identifying Gram-Negative Bacteria.Analytical science advances · 2026Article
- AI-Assisted Diagnosis ofDiagnostics (Basel, Switzerland) · 2026Article
- An annotated dataset of Gram stains from positive blood cultures.Scientific data · 2026Article
- Surface Mesoscopic Characterization and Analysis of Nanosecond-Laser-Processed Molybdenum for the Optimization of Antibacterial Performance.Nanomaterials (Basel, Switzerland) · 2025Article
- Improvement of gram staining effect by ethanol pretreatment and quantization of staining image by unsupervised machine learning.Archives of microbiology · 2024Article
- Multispectral in-line hologram reconstruction with aberration compensation applied to Gram-stained bacteria microscopy.Scientific reports · 2023Article
- The use of nanoparticles in the treatment of infectious diseases and cancer, dental applications and tissue regeneration: a review.Frontiers in medical technology · 2023Review
- Fluorescent optotracers for bacterial and biofilm detection and diagnostics.Science and technology of advanced materials · 2023Review
- Fc-MBL-modified FeMikrochimica acta · 2022Article
- Point-of-care cerebrospinal fluid Gram stain for the management of acute meningitis in adults: a retrospective observational study.Annals of clinical microbiology and antimicrobials · 2020Observational
- A Novel Improved Gram Staining Method Based on the Capillary Tube.Polish journal of microbiology · 2020Article
- Development of a standardized Gram stain procedure for bacteria and inflammatory cells using an automated staining instrument.MicrobiologyOpen · 2020Article
- Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances.Frontiers in chemistry · 2020Review
- Smartphone-based clinical diagnostics: towards democratization of evidence-based health care.Journal of internal medicine · 2019Review
- Waltzing around Sacred Cows on the Way to the Future.Journal of clinical microbiology · 2018Article
- Biographical Feature: Richard B. (Tom) Thomson, Jr., Ph.D., D(ABMM), F(AAM).Journal of clinical microbiology · 2018Article
- Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance.Pharmaceutics · 2018Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Gram stain is one of the most commonly performed tests in the clinical microbiology laboratory, yet it is poorly controlled and lacks standardization. It was once the best rapid test in microbiology, but it is no longer trusted by many clinicians. The publication by Samuel et al. (J. Clin. Microbiol. 54:1442-1447, 2016, http://dx.doi.org/10.1128/JCM.03066-15) is a start for those who want to evaluate and improve Gram stain performance. In an age of emerging rapid molecular results, is the Gram stain still relevant? How should clinical microbiologists respond to the call to reduce Gram stain error rates?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.