Evidence map›Paper›PMID 27008869›Full record

SynthesisHuman molecular genetics2016

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.

Maxine M Chen, Tracy A O'Mara, Deborah J Thompson, Jodie N Painter, Australian National Endometrial Cancer Study Group (ANECS), John Attia, Amanda Black, Louise Brinton, Stephen Chanock, Chu Chen and 55 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Association ofTurkish journal of obstetrics and gynecology · 2025
    Article
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  15. Article
  16. Genome-Wide Association Studies of Cancer in Diverse Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Review
  17. Endometrial cancer gene panels: clinical diagnostic vs research germline DNA testing.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors.

Maxine M ChenProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
Deborah J ThompsonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Jodie N PainterDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
Australian National Endometrial Cancer Study Group (ANECS)
John AttiaHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Amanda BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Louise BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Chu ChenFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Timothy Ht ChengWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Linda S CookUniversity of New Mexico, Albuquerque, NM 87131, USA.
Marta Crous-BouProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Jennifer DohertyGeisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.
Montserrat Garcia-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, GA 30329, USA.
Maggie GormanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Christopher HaimanUniversity of Southern California, Los Angeles, CA 90033, USA.
Susan E HankinsonChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Brian E HendersonUniversity of Southern California, Los Angeles, CA 90033, USA.
Shirley HodgsonDepartment of Clinical Genetics, St George's, University of London, London SW17 0RE, UK.
Elizabeth G HollidayHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Pamela L Horn-RossCancer Prevention Institute of California, Fremont, CA 94538, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Xiaolin LiangMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Jirong LongDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt - Ingram Cancer Center, Vanderbilt University Medical Center, Nashville TN 27232, USA.
Lingeng LuYale University School of Public Health, New Haven, CT 06510, USA.
Anthony M MaglioccoH Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Lynn MartinWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Mark McEvoySchool of Medicine and Public Health, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW 2308, Australia.
National Study Of Endometrial Cancer Genetics Group (NSECG)
Sara H OlsonMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Irene OrlowMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Loreall PoolerUniversity of Southern California, Los Angeles, CA 90033, USA.
Jennifer PrescottChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Radhai RastogiMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Timothy R RebbeckCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Harvey RischYale University School of Public Health, New Haven, CT 06510, USA.
Carlotta SacerdoteCenter for Cancer Prevention (CPO-Piemonte), Turin, Italy.
Frederick SchumacherUniversity of Southern California, Los Angeles, CA 90033, USA.
Veronica Wendy SetiawanUniversity of Southern California, Los Angeles, CA 90033, USA.
Rodney J ScottHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Xin ShengUniversity of Southern California, Los Angeles, CA 90033, USA.
Xiao-Ou ShuDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt - Ingram Cancer Center, Vanderbilt University Medical Center, Nashville TN 27232, USA.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
David Van Den BergUniversity of Southern California, Los Angeles, CA 90033, USA.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Noel S WeissUniversity of Washington, Seattle, WA 19024, USA.
Nicholas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Lucy XiaUniversity of Southern California, Los Angeles, CA 90033, USA.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China and.
Hannah P YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Herbert YuUniversity of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Wei ZhengDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt - Ingram Cancer Center, Vanderbilt University Medical Center, Nashville TN 27232, USA.
Paul D P PharoahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Alison M DunningDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Ian TomlinsonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Douglas F EastonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
Immaculata De VivoProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA, nhidv@channing.harvard.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCERR01CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1993 to 2002
$4.5M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 16565NCI NIH HHS K05 CA092002NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA082838NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA091019NCI NIH HHS R01 CA105212NCI NIH HHS R01 CA134958NCI NIH HHS R03 CA080636NCI NIH HHS R03 CA128008NCI NIH HHS R35 CA197449NCI NIH HHS R37 CA054281NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA186107NICHD NIH HHS N01 HD023166Wellcome Trust
6 · The paper itself

Abstract

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyChromosomes, Human, Pair 6Endometrial NeoplasmsFemaleGenotypeHumansPolymorphism, Single NucleotideWhite People

Identifiers

PMID27008869
PMCPMC5868213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.