ArticleOncotarget2016
C-phycocyanin protects against low fertility by inhibiting reactive oxygen species in aging mice.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.Journal of ovarian research · 2025Trial
- C-phycocyanin protects against obesity-associated type 2 diabetes-induced male fertility dysfunction via key enzyme regulation.Asian journal of andrology · 2026Article
- Multi-tissue analysis identifies mitochondrial genes in chicken aging-induced productivity decline.Journal of animal science and biotechnology · 2026Article
- C-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model.Journal of ovarian research · 2026Article
- Astaxanthin prevents postovulatory oocyte aging by targeting TNFR2 and inhibiting the TNF signaling pathway.BMC biology · 2025Article
- Protective effects of Spirulina platensis and phycocyanin on sperm quality, DNA integrity, and testicular tissue following oxidative stress in rats: An experimental study.International journal of reproductive biomedicine · 2025Article
- Algal and Fungal Antioxidants Alleviate Oxidative Stress-Induced Reproductive Defects.Food science & nutrition · 2025Review
- Protective Effect ofBiopreservation and biobanking · 2024Article
- COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice.Molecular neurobiology · 2024Article
- Review
- C-phycocyanin improves the developmental potential of cryopreserved human oocytes by minimizing ROS production and cell apoptosis.PloS one · 2024Article
- Nicotinamide Riboside and Phycocyanin Oligopeptides Affect Stress Susceptibility in Chronic Corticosterone-Exposed Rats.Antioxidants (Basel, Switzerland) · 2023Article
- C-Phycocyanin Ameliorates the Senescence of Mesenchymal Stem Cells through ZDHHC5-Mediated Autophagy via PI3K/AKT/mTOR Pathway.Aging and disease · 2023Article
- Importance of Antioxidant Supplementation during In Vitro Maturation of Mammalian Oocytes.Veterinary sciences · 2022Review
- Anti-Aging Effects of R-Phycocyanin fromMarine drugs · 2022Article
- DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies.Human reproduction update · 2022Review
- Phycobiliproteins extract from Spirulina protects against single-dose cadmium-induced reproductive toxicity in male mice.Environmental science and pollution research international · 2022Article
- Protective effects of ginseng stem-leaf saponins on D-galactose-induced reproductive injury in male mice.Aging · 2021Article
- Article
- Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.Frontiers in physiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women over 35 have higher rates of infertility, largely due to deterioration of oocyte quality characterized by fragmentation, abnormal meiotic spindle-chromosome complexes, and oxidative stress. C-phycocyanin (PC) is a biliprotein enriched in Spirulina platensis that is known to possess antioxidant, anti-inflammatory, and radical-scavenging properties. D-galactose-induced aging acceleration in mice has been extensively used to study aging mechanisms and for pharmaceutical screening. In this study, adult female B6D2F/1 mice injected with D-galactose were used as a model to test the age-reversing effects of PC on degenerated reproductive ability. Our results show that PC can prevent oocyte fragmentation and aneuploidy by maintaining cytoskeletal integrity. Moreover, PC can reverse the expression of antioxidant genes, increase superoxide dismutase (SOD) activity and decrease methane dicarboxylic aldehyde (MDA) content, and normalize mitochondria distribution. PC exerts its benefit by inhibiting reactive oxygen species (ROS) production, which decreases apoptosis. Finally, we observe a significant increase in litter size after PC administration to D-galactose-induced aging mice. Our study demonstrates for the first time that D-galactose-induced impaired female reproductive capability can be partially rescued by the antioxidant effects of PC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.