ArticlePediatric nephrology (Berlin, Germany)2016
Normalization of glomerular filtration rate in obese children.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Indexing for body surface area when assessing kidney function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Influence of genetics on clinical trajectories in children with MASLD: role of the PNPLA3 I148M polymorphism.Journal of endocrinological investigation · 2026Observational
- Pharmacokinetics and Childhood Obesity: Pathophysiological Basis and Challenges in Choosing the Ideal Body Size Descriptor.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Role of subclinical hypothyroidism on kidney damage in children with obesity.International journal of obesity (2005) · 2025Article
- Role of metabolic dysfunction-associated steatotic liver disease and of its genetics on kidney function in childhood obesity.International journal of obesity (2005) · 2025Article
- The Impact of Paediatric Obesity on Drug Pharmacokinetics: A Virtual Clinical Trials Case Study with Amlodipine.Pharmaceutics · 2024Article
- Kidney damage predictors in children with metabolically healthy and metabolically unhealthy obesity phenotype.International journal of obesity (2005) · 2023Article
- What to do with kidney length and volumes in large individuals?Pediatric nephrology (Berlin, Germany) · 2023Article
- Creatinine-based GFR-estimating equations in children with overweight and obesity.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Relation of glomerular filtration to insulin resistance and related risk factors in obese children.International journal of obesity (2005) · 2022Article
- Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.Clinical pharmacokinetics · 2022Article
- Characterizing Pharmacokinetics in Children With Obesity-Physiological, Drug, Patient, and Methodological Considerations.Frontiers in pharmacology · 2022Review
- Obesity Facts and Their Influence on Renal Function Across the Life Span.Frontiers in medicine · 2021Review
- Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.International journal of epidemiology · 2020Article
- The effects of obesity on kidney function: a challenge for nephrologists.Jornal brasileiro de nefrologia · 2019Article
- The effect of one year lifestyle intervention on eGFR in children and adolescents with overweight, obesity and morbid obesity.Scientific reports · 2019Article
- Educational review: measurement of GFR in special populations.Pediatric nephrology (Berlin, Germany) · 2018Review
- Weight trajectories and kidney function in early childhood.Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlomerular filtration rate (GFR) is conventionally indexed to body surface area (BSA), but this may lead to biased results when applied to subjects of abnormal body size. The aim of our study was to examine the impact of normalization to the BSA and alternative body size descriptors on measured and estimated GFR in overweight and obese children.
methodsThis was a cross-sectional study of 313 children aged 8-9 years old. GFR was measured by 24-h creatinine clearance (CrCl) and additionally estimated from serum creatinine and cystatin C (CysC) using the combined Zappitelli formula, both as absolute values and adjusted to various body size descriptors. The results were compared between 163 normal-weight, 89 overweight and 61 obese children.
resultsCompared to the normal-weight children, mean absolute GFR (both measured and estimated) was higher in the overweight and obese children, whereas BSA-adjusted GFR was lower. Linear regression models fitted in normal-weight children revealed equally close associations between absolute GFR and squared height, ideal body weight (IBW) and BSA derived from IBW. Normalization of GFR to the IBW-derived BSA completely eliminated the discrepancy between absolute and BSA-indexed GFR in overweight and obese children.
conclusionsIndexing of GFR to BSA calculated from the ideal-rather than actual-body weight is a promising approach to avoid overcorrection when studying obese children. Further studies should assess the accuracy of this approach across the full range of age and BMI distribution.
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