ArticleDiabetologia2016
Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population.
Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Mesenchymal stem cells receive adaptive islet-derivedScience advances · 2026Article
- Subphenotyping of prediabetes with a phenotypic tree model and its correlations with outcomes: Insights from two Chinese cohorts.Journal of translational internal medicine · 2026Article
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- Global Mortality and Disability-Adjusted Life Years Attributable to Tobacco Exposure Among Middle-Aged and Older Adults With Type 2 Diabetes, 1990-2021: A Systematic Analysis of GBD 2021 Data With Projections to 2042.Journal of diabetes research · 2026Article
- Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population.Reviews in endocrine & metabolic disorders · 2025Review
- Diabetes in China: epidemiology, pathophysiology and multi-omics.Nature metabolism · 2025 · on this mapReview
- Ten metabolites-based algorithm predicts the future development of type 2 diabetes in Chinese.Journal of advanced research · 2024Article
- Biological Activity of Lactic Acid Bacteria Exopolysaccharides and Their Applications in the Food and Pharmaceutical Industries.Foods (Basel, Switzerland) · 2024Review
- The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study.BMC endocrine disorders · 2023Article
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- Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2021Article
- Functional Status of PancreaticInternational journal of endocrinology · 2021Article
- Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor.The Journal of clinical investigation · 2020Article
- Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes.Cardiovascular diabetology · 2019Observational
- Alcohol consumption and its interaction with genetic variants are strongly associated with the risk of type 2 diabetes: a prospective cohort study.Nutrition & metabolism · 2019Article
- Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study.Diabetologia · 2017Article
- Article
- Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomization analysis.International journal of obesity (2005) · 2016Article
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12 authors.
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Abstract
aims/hypothesisWe aimed to evaluate the combined effects of type 2 diabetes risk variants on predicting deterioration of blood glucose and progression of beta cell function and insulin sensitivity in a 9 year prospective cohort from the Chinese population.
methodsWe constructed a weighted genetic risk score (GRS) model based on 40 variants associated with type 2 diabetes validated in an established cross-sectional Chinese population (n = 6,822). The weighted scores were categorised into tertiles to assess the predictive capacity for incidence of type 2 diabetes and impaired glucose regulation (IGR), as well as for changes in Stumvoll first- and second-phase insulin secretion indices and Gutt's insulin sensitivity index (ISI) in a community-based 9 year prospective cohort (n = 2,495), including 2,192 individuals with normal glucose tolerance and 303 with IGR at baseline, through logistic, Cox and multiple linear regression tests.
resultsWeighted GRS predicted the incidence of type 2 diabetes and IGR in logistic regression (OR 1.236, 95% CI 1.100, 1.389, p = 0.0004) as well as in the Cox model (HR 1.129, 95% CI 1.026, 1.242, p = 0.0128) after adjusting for age, sex, BMI, smoking and alcohol status at baseline. Moreover, we observed that weighted GRS was able to predict deterioration in beta cell function (β = -0.0480, p = 9.66 × 10(-5) and β = -0.0303, p = 3.32 × 10(-5) for first- and second-phase insulin secretion, respectively), but not insulin sensitivity (p = 0.3815), during the 9 year follow-up period. CONCLUSIONS/
interpretationThe weighted GRS predicted blood glucose deterioration arising from change in beta cell function in the Chinese population. Individuals in the intermediate- or high-weighted GRS group exhibited progressive deterioration of beta cell function.
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