Evidence map›Paper›PMID 27008620›Full record

Trial reportPloS one2016

A Randomised Controlled Trial of Neuronavigated Repetitive Transcranial Magnetic Stimulation (rTMS) in Anorexia Nervosa.

Jessica McClelland, Maria Kekic, Natali Bozhilova, Steffen Nestler, Tracy Dew, Frederique Van den Eynde, Anthony S David, Katya Rubia, Iain C Campbell, Ulrike Schmidt

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04077502 (Repetitive Transcranial Magnetic Stimulation in Treatment of Binge Eating Disorder. A Double Blind Placebo Controlled Study), which is not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04077502 naunknown statusnot on this map

Repetitive Transcranial Magnetic Stimulation in Treatment of Binge Eating Disorder. A Double Blind Placebo Controlled Study

TypeinterventionalSponsorCharles University, Czech RepublicRan2014 to 2019Enrolled12ConditionsBinge-Eating DisorderArmsRepetitive Transcranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. rTMS Therapy for Eating Disorders: Scoping Review on Efficacy, Safety, Stimulation Parameters and Study Subjects.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Review
  9. Article
  10. Anorexia Nervosa Across the Lifespan: A Review of Recent Literature.Focus (American Psychiatric Publishing) · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Body appearance values modulate risk aversion in eating restriction.Journal of experimental psychology. General · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Impact of one HF-rTMS session over the DLPFC and motor cortex on acute hormone dynamics and emotional state in healthy adults: a sham-controlled pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jessica McClellandInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Maria KekicInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Natali BozhilovaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Steffen NestlerInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Tracy DewDepartment of Clinical Biochemistry, King's College Hospital, London, United Kingdom.
Frederique Van den EyndeNeuromodulation Research Clinic, Douglas Mental Health University Institute, Montréal, Québec, Canada.
Anthony S DavidInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Katya RubiaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Iain C CampbellInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Ulrike SchmidtInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
King's College London · GBDouglas Mental Health University Institute · CAKing's College Hospital · GB

Funding

Department of Health PB-PG-1013-32049
6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) is associated with morbid fear of fatness, extreme food restriction and altered self-regulation. Neuroimaging data implicate fronto-striatal circuitry, including the dorsolateral prefrontal cortex (DLPFC).

methodsIn this double-blind parallel group study, we investigated the effects of one session of sham-controlled high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC (l-DLPFC) in 60 individuals with AN. A food exposure task was administered before and after the procedure to elicit AN-related symptoms. OUTCOMES: The primary outcome measure was 'core AN symptoms', a variable which combined several subjective AN-related experiences. The effects of rTMS on other measures of psychopathology (e.g. mood), temporal discounting (TD; intertemporal choice behaviour) and on salivary cortisol concentrations were also investigated. Safety, tolerability and acceptability were assessed.

resultsFourty-nine participants completed the study. Whilst there were no interaction effects of rTMS on core AN symptoms, there was a trend for group differences (p = 0.056): after controlling for pre-rTMS scores, individuals who received real rTMS had reduced symptoms post-rTMS and at 24-hour follow-up, relative to those who received sham stimulation. Other psychopathology was not altered differentially following real/sham rTMS. In relation to TD, there was an interaction trend (p = 0.060): real versus sham rTMS resulted in reduced rates of TD (more reflective choice behaviour). Salivary cortisol concentrations were unchanged by stimulation. rTMS was safe, well-tolerated and was considered an acceptable intervention.

conclusionsThis study provides modest evidence that rTMS to the l-DLPFC transiently reduces core symptoms of AN and encourages prudent decision making. Importantly, individuals with AN considered rTMS to be a viable treatment option. These findings require replication in multiple-session studies to evaluate therapeutic efficacy.

trial registrationwww.Controlled-Trials.com ISRCTN22851337.

Indexed as

AdultAffectAnorexia NervosaDouble-Blind MethodFemaleHumansHydrocortisoneMalePrefrontal CortexTranscranial Magnetic StimulationYoung AdultHydrocortisone

Identifiers

PMID27008620
PMCPMC4805273
OpenAlexW2304381542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.