Evidence map›Paper›PMID 27008595›Full record

ReviewCurrent opinion in nephrology and hypertension2016

Intravital imaging in the kidney.

János Peti-Peterdi, Kengo Kidokoro, Anne Riquier-Brison

Abstract readReview
In one paragraph

Review in Current opinion in nephrology and hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A new view of macula densa cell protein synthesis.American journal of physiology. Renal physiology · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Advances in Renal Cell Imaging.Seminars in nephrology · 2018
    Review
  10. Article
  11. Review
  12. Deep insights: intravital imaging with two-photon microscopy.Pflugers Archiv : European journal of physiology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

János Peti-PeterdiaDepartments of Physiology and Biophysics, and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA bDepartment of Nephrology and Hypertension, Kawasaki Medical School, Kurashiki, Japan.
Kengo Kidokoro
Anne Riquier-Brison

Funding

Multiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4M
Novel imaging approach to study podocyte function in vivoR01DK100944 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PETI-PETERDI, JANOS · 2014 to 2017
$1.5M
NIDDK NIH HHS DK100944NIDDK NIH HHS DK64324NIDDK NIH HHS R01 DK064324NIDDK NIH HHS R01 DK100944
6 · The paper itself

Abstract

purpose of reviewThe review aims to provide a brief summary and evaluation of the current state of research that uses multiphoton fluorescence microscopy for intravital kidney imaging. RECENT

findingsDirect visualization of the glomerular filter, proximal and distal tubule segments, and the renal vasculature in the living, intact kidney in zebrafish, mouse, and rat models with high temporal and spatial resolution provided new insights into the function of the normal and diseased kidney. New technical developments in fluorescence excitation and detection, in combination with transgenic animal models for cell function and fate mapping, and serial imaging of the same glomerulus in the same animal over several days further advanced the field of nephrology research, and the understanding of disease mechanisms. SUMMARY: Intravital multiphoton imaging has solved many critical technical barriers in kidney research and allowed the dynamic portrayal of the structure and function of various renal cell types in vivo. It has become a widely used research technique, with significant past achievements, and tremendous potential for future development and applications for the study and better understanding of kidney diseases.

Indexed as

Intravital MicroscopyMicroscopy, Fluorescence, MultiphotonAnimalsEpithelial CellsHumansKidneyKidney DiseasesModels, Animal

Identifiers

PMID27008595
PMCPMC4868545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.