Evidence map›Paper›PMID 27008577›Full record

Trial reportSurgical endoscopy2016

Peri-incisional and intraperitoneal ropivacaine administration: a new effective tool in pain control after laparoscopic surgery in gynecology: a randomized controlled clinical trial.

Carlo Saccardi, Salvatore Gizzo, Amerigo Vitagliano, Marco Noventa, Massimo Micaglio, Matteo Parotto, Mauro Fiorese, Pietro Litta

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Carlo SaccardiDepartment of Woman and Child Health, University of Padua, Giustiniani 3, 35128, Padua, Italy.
Salvatore GizzoDepartment of Woman and Child Health, University of Padua, Giustiniani 3, 35128, Padua, Italy.
Amerigo VitaglianoDepartment of Woman and Child Health, University of Padua, Giustiniani 3, 35128, Padua, Italy. amerigovitagliano.md@gmail.com.
Marco NoventaDepartment of Woman and Child Health, University of Padua, Giustiniani 3, 35128, Padua, Italy.
Massimo MicaglioDepartment of Anesthesia and Intensive Care, Careggi University Hospital, Florence, Italy.
Matteo ParottoDepartment of Anesthesia, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Mauro FioreseDipartimento Materno Infantile U.O.C. di Ostetricia e Ginecologia, U.L.S.S. N. 4 Alto Vicentino, Thiene, Italy.
Pietro LittaDepartment of Woman and Child Health, University of Padua, Giustiniani 3, 35128, Padua, Italy.
University of Padua · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA proportion of patients undergoing laparoscopic gynecological surgery experiences excessive post-operative pain, which results in high rescue analgesic treatment and prolonged hospitalization. The aim of our study was to evaluate the efficacy of intraoperative topical ropivacaine in the control of post-operative pain in the first 48 h after operative laparoscopy for benign adnexal or uterine pathologies .

methodsWe conducted a prospective, randomized, double-blind, placebo-controlled clinical trial. Patients received a standard dose of topical ropivacaine (injected at the three portal sites and atomized in the abdominal cavity) or placebo. The primary outcome was the evaluation of post-operative pain intensity 6 h after surgery. Secondary outcomes included the intensity of pain during the 48 h after surgery, shoulder tip pain and the request for rescue analgesics during the first 48 h after surgery, time to discharge from recovery room, time to mobilizing on the ward and time to return to daily activities. Patients were divided in two groups (Group_A: benign adnexal pathologies; Group_B: benign uterine diseases) and assigned to Subgroup_1 (receiving ropivacaine) and Subgroup_2 (receiving placebo).

resultsA total of 187 women were included: 93 in Group_A and 94 in Group_B. Forty-seven patients entered Subgroup_A1, 46 Subgroup_A2, 48 Subgroup_B1 and 46 Subgroup_B2. Subgroup_A1 experienced lower post-operative pain at 4 (p = 0.008) and 6 h (p = 0.001) as well as a faster return to daily activities (p = 0.01) in comparison with Subgroup_A2. Both Subgroup_A1 and Subgroup_B1 showed lower shoulder tip pain (respectively, p = 0.032 and p = 0.001) as well as shorter time to mobilizing on the ward after surgery (respectively, p = 0.001 and p = 0.01). The remaining variables analysis did not show significant results.

conclusionsCombined topical analgesia with ropivacaine could represent a new safe and effective tool in the control of post-operative pain in gynecological laparoscopic surgery. Given the greater benefits for adnexal surgery, this strategy may be more suitable for this class of patients.

Indexed as

AdultAmidesAnesthetics, LocalDouble-Blind MethodFemaleGynecologic Surgical ProceduresHumansInjections, IntraperitonealLaparoscopyMiddle AgedPain ManagementPain MeasurementPostoperative PainProspective StudiesRopivacaineShoulder PainAmidesAnesthetics, LocalRopivacaineAdnexal pathologyGynecological laparoscopic surgeryPost-operative painRopivacaineTopic analgesiaUterine pathology

Identifiers

PMID27008577
OpenAlexW2307962313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.