Evidence map›Paper›PMID 27008505›Full record

ArticlePloS one2016

RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.

Xiaoming Wang, Minran Zhou, Yue Fu, Ting Sun, Jin Chen, Xuemei Qin, Yuan Yu, Jihui Jia, Chunyan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Significance ofOxidative medicine and cellular longevity · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiaoming WangDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Minran ZhouDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Yue FuDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Ting SunDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Jin ChenAnhui Medical College, Hefei, Anhui, P. R. China.
Xuemei QinDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Yuan YuDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Jihui JiaDepartment of Microbiology/Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine, Shandong University, Jinan, Shandong, P. R. China.
Chunyan ChenDepartment of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
Qilu Hospital of Shandong University · CNAnhui Medical University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite recent increases in the cure rate of acute lymphoblastic leukemia (ALL), adult ALL remains a high-risk disease that exhibits a high relapse rate. In this study, we found that the histone demethylase retinoblastoma binding protein-2 (RBP2) was overexpressed in both on-going and relapse cases of adult ALL, which revealed that RBP2 overexpression was not only involved in the pathogenesis of ALL but that its overexpression might also be related to relapse of the disease. RBP2 knockdown induced apoptosis and attenuated leukemic cell viability. Our results demonstrated that BCL2 is a novel target of RBP2 and supported the notion of RBP2 being a regulator of BCL2 expression via directly binding to its promoter. As the role of RBP2 in regulating apoptosis was confirmed, RBP2 overexpression and activation of BCL2 might play important roles in ALL development and progression.

Indexed as

AdultApoptosisBlotting, WesternChromatin ImmunoprecipitationDisease ProgressionFlow CytometryFluorescent Antibody TechniqueGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticProto-Oncogene Proteins c-bcl-2Real-Time Polymerase Chain ReactionRetinol-Binding Proteins, CellularUp-RegulationBCL2 protein, humanProto-Oncogene Proteins c-bcl-2RBP2 protein, humanRetinol-Binding Proteins, Cellular

Identifiers

PMID27008505
PMCPMC4805198
OpenAlexW2307229837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.