ArticleJournal of applied oral science : revista FOB
Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Impact of Vitamin D on Osseointegration in Dental Implants: A Systematic Review of Human Studies.Nutrients · 2024Pooled it
- Does vitamin D have an effect on osseointegration of dental implants? A systematic review.International journal of implant dentistry · 2022Pooled it
- Complex Analysis of Micronutrient Levels and Bone Mineral Density in Patients with Different Types of Osteogenesis Imperfecta.Diagnostics (Basel, Switzerland) · 2025Article
- Micro-Computed Tomography as a complementary tool for histopathological diagnosis of oral soft tissue lesions - Proof of concept.PloS one · 2025Article
- Resonance frequency analysis of dental implants in patients with vitamin D deficiency.Clinical oral investigations · 2024Article
- Can Vitamin D Levels Influence Bone Metabolism and Osseointegration of Dental Implants? An Umbrella Review.Healthcare (Basel, Switzerland) · 2024Review
- The role of Vitamin D as an adjunct for bone regeneration: A systematic review of literature.The Saudi dental journal · 2023Review
- Peri-Implant Repair Using a Modified Implant Macrogeometry in Diabetic Rats: Biomechanical and Molecular Analyses of Bone-Related Markers.Materials (Basel, Switzerland) · 2022Article
- Do Dietary Supplements and Nutraceuticals Have Effects on Dental Implant Osseointegration? A Scoping Review.Nutrients · 2020Article
- Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies.BioMed research international · 2018Review
- Osteonecrosis of the Jaw in Post-Bariatric Patients: An Underestimated Risk in Oral Surgery? Clinical Implications and Perspectives.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe use of natural substances and micronutritional approaches has been suggested as a therapeutic alternative to benefit the bone healing associated with no side effects. Nevertheless, the influence of micronutritional interventions with therapeutic proprieties on the bone repair has yet to be intensely evaluated, and no evidence is available exploring the impact of micronutrient supplementation on the peri-implant bone healing.
objectiveThis study investigated the effect of micronutrients supplementation on the bone repair around implants. MATERIAL AND
methodsOne screw-shaped titanium implant was inserted in each tibia of each rat, which were assigned to: daily administration, for 30 d, of the placebo solution (Placebo group-n:18) or micronutrients supplementation (Micronutrients group-n:18), based on calcium, magnesium, zinc, and vitamin D3 intake. After, the animals were sacrificed. One of the implants was removed by applying a counter-torque force to evaluate the force to rupture the bone-implant interface. The other implant was evaluated by microcomputed tomography (CT) examination to determine the bone-to-implant contact (BIC) and the bone volume (BV/TV).
resultsNo statistically significant differences were observed between the groups for both counter-torque values and microCT parameters (p>0.05).
conclusionWithin the limits of this study, micronutrients supplementation did not provide additional benefits to the bone healing around dental implants.
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Registered trials
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