ArticleCognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology2016
Neurobehavioral Disturbances During Acute and Early HIV Infection.
Article in Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis.Journal of clinical and experimental neuropsychology · 2018Pooled it
- Self-initiated continuation of and adherence to HIV pre-exposure prophylaxis (PrEP) after PrEP demonstration project roll-off in men who have sex with men: associations with risky decision making, impulsivity/disinhibition, and sensation seeking.Journal of neurovirology · 2019Trial
- THC induced similar physiological effects on HIV transgenic rats and their controls without affecting HIV-induced deficits in effortful motivation.Journal of cannabis research · 2026Article
- Does Social Support Play a Role in the Expression and Everyday Functioning Impact of Apathy in HIV Disease?AIDS and behavior · 2024Article
- Central Nervous System Effects of Early HIV Infection and Consequences of Antiretroviral Therapy Initiation during Acute HIV.Viruses · 2024Review
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- An evaluation of the moderating effects of routine and busyness on the relationship between prospective memory and everyday functioning in older persons with HIV disease.Journal of clinical and experimental neuropsychology · 2024Article
- Human iPSC-derived brain organoids: A 3D mini-brain model for studying HIV infection.Experimental neurology · 2023Article
- Synaptic dysfunction is associated with alterations in the initiation of goal-directed behaviors: Implications for HIV-1-associated apathy.Experimental neurology · 2022Article
- Apathy is not associated with a panel of biomarkers in older adults with HIV disease.Journal of psychosomatic research · 2022Article
- HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.Cells · 2021Review
- Utility of a Short Neuropsychological Protocol for Detecting HIV-Associated Neurocognitive Disorders in Patients with Asymptomatic HIV-1 Infection.Brain sciences · 2021Article
- Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances.Journal of neurovirology · 2020Article
- Successful Functional Aging in Middle-Aged and Older Adults with HIV.AIDS and behavior · 2020Article
- The current understanding of overlap between characteristics of HIV-associated neurocognitive disorders and Alzheimer's disease.Journal of neurovirology · 2019Review
- Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Frequency and Correlates of Subjective Cognitive Impairment in HIV Disease.AIDS and behavior · 2019Article
- Associations between Depressive Symptomatology and Neurocognitive Impairment in HIV/AIDS.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Article
- Affective immunology: where emotions and the immune response converge.Dialogues in clinical neuroscience · 2017Review
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
objectiveAcute and early human immunodeficiency virus infection (AEH) is accompanied by neuroinflammatory processes as well as impairment in neurocognitive and everyday functions, but little is known about the frequency and clinical correlates of the neurobehavioral disturbances during this period. We compared pre-seroconversion with current levels of apathy, disinhibition, and executive dysfunction; we also examined everyday function and HIV disease correlates of neuropsychiatric impairment in individuals with AEH.
methodsIn this study, 34 individuals with AEH and 39 HIV-seronegative participants completed neuromedical and neuropsychological assessments, a structured psychiatric interview, and the apathy, disinhibition, and executive dysfunction subscales of the Frontal Systems Behavioral Scale.
resultsIndependent of any substance use and mood disorders, the AEH group had significantly higher levels of current apathy and executive dysfunction than the controls, but not greater disinhibition. Retrospective ratings of pre-seroconversion levels of apathy, disinhibition, and executive dysfunction were all higher in the AEH group than the controls. After seroconversion, the AEH cohort had increases in current apathy and executive dysfunction, but not disinhibition. In the AEH cohort, higher current global neurobehavioral dysfunction was significantly associated with lower nadir CD4 counts, slowed information processing speed, and more everyday function problems.
conclusionsThese data suggest that individuals who have recently acquired HIV experienced higher-than-normal premorbid levels of neurobehavioral disturbance. Apathy and executive dysfunction are exacerbated during AEH, particularly in association with lower CD4 counts.
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