Observational studyJournal of neurology2016
Clinical features and prognostic factors of spinal cord sarcoidosis: a multicenter observational study of 20 BIOPSY-PROVEN patients.
Observational study in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Clinical characteristics and outcome of neurosarcoidosis-associated myelitis: A retrospective cohort study and review of the literature.European journal of neurology · 2022Pooled it
- A Case Report of an Intradural Extramedullary Tumor, Which Was Treated With Steroid and Clinically Suspected as Neural Sarcoidosis.Case reports in orthopedics · 2026Article
- Neuropsychiatric manifestations of sarcoidosis.Annals of medicine · 2025Review
- Cranial MRI in neurosarcoidosis: Imaging patterns and nationwide clinical correlations.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Autoimmune diseases of the spine and spinal cord.The neuroradiology journal · 2024Review
- Neurosarcoidosis.Journal of neurology · 2024Article
- Sarcoidosis Presenting as Longitudinally Extensive Transverse Myelitis: A Case Report.Journal of the Belgian Society of Radiology · 2024Article
- Article
- A comprehensive diagnostic approach in suspected neurosarcoidosis.Scientific reports · 2023Article
- Insights into neurosarcoidosis: an imaging perspective.Polish journal of radiology · 2023Review
- Spinal Cord Sarcoidosis Occurring at Sites of Spondylotic Stenosis, Mimicking Spondylotic Myelopathy: A Case Series and Review of the Literature.AJNR. American journal of neuroradiology · 2023Review
- Spinal cord sarcoidosis in Japan: utility of cerebrospinal fluid examination and nerve conduction study for diagnosis and prognosis prediction.Journal of neurology · 2022Article
- Neurosarcoidosis of the Cauda Equina: Clinical Course, Radiographic and Electrodiagnostic Findings, Response to Treatment, and Outcomes.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- Epidemiology, clinical presentation, treatment, and outcome of neurosarcoidosis: A mono-centric retrospective study and literature review.Frontiers in neurology · 2022Article
- Neurosarcoidosis: Pathophysiology, Diagnosis, and Treatment.Neurology(R) neuroimmunology & neuroinflammation · 2021Review
- Clinical characterization and outcomes of 85 patients with neurosarcoidosis.Scientific reports · 2021Article
- Extrapulmonary sarcoidosis with a focus on cardiac, nervous system, and ocular involvement.EClinicalMedicine · 2021Review
- [Differential diagnostics of autoimmune inflammatory spinal cord diseases].Der Nervenarzt · 2021Review
- Review
- Overcoming the Elusiveness of Neurosarcoidosis: Learning from Five Complex Cases.Neurology international · 2021Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcoidosis of the spinal cord is a rare disease. The aims of this study are to describe the features of spinal cord sarcoidosis (SCS) and identify prognostic markers. We analyzed 20 patients over a 20-year period in 8 French hospitals. There were 12 men (60 %), mostly Caucasian (75 %). The median ages at diagnosis of sarcoidosis and myelitis were 34.5 and 37 years, respectively. SCS revealed sarcoidosis in 12 patients (60 %). Eleven patients presented with motor deficit (55 %) and 9 had sphincter dysfunction (45 %). The median initial Edmus Grading Scale (EGS) score was 2.5. The cerebrospinal fluid (CSF) showed elevated protein level (median: 1.00 g/L, interquartile range (IQR) 0.72-1.97), low glucose level (median 2.84 mmol/L, IQR 1.42-3.45), and elevated white cell count (median 22/mm(3), IQR 6-45). The cervical and thoracic cords were most often affected (90 %). All patients received steroids and an immunosuppressive drug was added in 10 cases (50 %). After a mean follow-up of 52.1 months (range 8-43), 18 patients had partial response (90 %), 7 displayed functional impairment (35 %), and the median final EGS score was 1. Six patients experienced relapse (30 %). There was an association between the initial and the final EGS scores (p = 0.006). High CSF protein level showed a trend toward an association with relapse (p = 0.076). The spinal cord lesion was often the presenting feature of sarcoidosis. Most patients experienced clinical improvement with corticosteroids and/or immunosuppressive treatment. The long-term functional prognosis was correlated with the initial severity.
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