ArticleCognitive behaviour therapy2016
Exposure-based Interventions for the management of individuals with high levels of needle fear across the lifespan: a clinical practice guideline and call for further research.
Article in Cognitive behaviour therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Reducing distress during vaccine injections: 2026 clinical practice guideline update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Guideline
- Efficacy and safety of vapocoolant spray for vascular puncture in children and adults: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Psychological interventions for needle-related procedural pain and distress in children and adolescents.The Cochrane database of systematic reviews · 2018Pooled it
- A randomized controlled trial on virtual reality distraction during venous cannulation in young children.Acta anaesthesiologica Scandinavica · 2022Trial
- Rapid Improvement in Neck Disability, Mobility, and Sleep Quality with Chronic Neck Pain Treated by Fu's Subcutaneous Needling: A Randomized Control Study.Pain research & management · 2022Trial
- The number of injected same-day preschool vaccines relates to preadolescent needle fear and HPV uptake.Vaccine · 2017Trial
- Automated virtual reality therapy to treat needle fears (trypanophobia) in adolescents in England: a proof-of-concept cohort study and a Phase II randomised controlled trial.EClinicalMedicine · 2026Article
- Procedural Support for Neurodivergent Children During Medical Procedures: A Scoping Review.Clinical child and family psychology review · 2026Article
- Coping with Pokes: Child, Caregiver, and Clinician Feedback on a Caregiver-Led Educational Resource for Managing Children's Needle Fear.Nursing reports (Pavia, Italy) · 2026Article
- Factors associated with documented distress during venipuncture in routine health checkups.Frontiers in psychiatry · 2026Article
- Procedural pain in pediatric care: educational, ethical, and public health imperatives.Frontiers in pediatrics · 2026Article
- Examining the relationship between perceived fear of pain and empathic tendencies of nursing students and the affecting factors: a cross-sectional study.BMC nursing · 2025Article
- Needle phobia in emergency department in a rural district hospital of Nepal: A cross-sectional analysis.PLOS mental health · 2025Article
- Prevalence, factors associated and management of needle phobia among the general population in Saudi Arabia and Egypt.BMC psychiatry · 2024Article
- Creating a Low-Stimulus Clinic to improve immunization success rates for children with alternate environment needs: A quality improvement initiative.Paediatrics & child health · 2024Article
- EANM procedural recommendations for managing the paediatric patient in diagnostic nuclear medicine.European journal of nuclear medicine and molecular imaging · 2023Review
- Urinary Metabolite Profiling to Non-Invasively Monitor the Omega-3 Index: An Exploratory Secondary Analysis of a Randomized Clinical Trial in Young Adults.Metabolites · 2023Article
- Picturing Bravery: A Rapid Review of Needle Procedures Depicted in Children's Picture Books.Children (Basel, Switzerland) · 2023Article
- Injection fears and COVID-19 vaccine hesitancy.Psychological medicine · 2023Article
- Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial.SAGE open medicine · 2023Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
Needle fear typically begins in childhood and represents an important health-related issue across the lifespan. Individuals who are highly fearful of needles frequently avoid health care. Although guidance exists for managing needle pain and fear during procedures, the most highly fearful may refuse or abstain from such procedures. The purpose of a clinical practice guideline (CPG) is to provide actionable instruction on the management of a particular health concern; this guidance emerges from a systematic process. Using evidence from a rigorous systematic review interpreted by an expert panel, this CPG provides recommendations on exposure-based interventions for high levels of needle fear in children and adults. The AGREE-II, GRADE, and Cochrane methodologies were used. Exposure-based interventions were included. The included evidence was very low quality on average. Strong recommendations include the following. In vivo (live/in person) exposure-based therapy is recommended (vs. no treatment) for children seven years and older and adults with high levels of needle fear. Non-in vivo (imaginal, computer-based) exposure (vs. no treatment) is recommended for individuals (over seven years of age) who are unwilling to undergo in vivo exposure. Although there were no included trials which examined children < 7 years, exposure-based interventions are discussed as good clinical practice. Implementation considerations are discussed and clinical tools are provided. Utilization of these recommended practices may lead to improved health outcomes due to better health care compliance. Research on the understanding and treatment of high levels of needle fear is urgently needed; specific recommendations are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.