ArticleMolecular endocrinology (Baltimore, Md.)2016
Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.
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Article in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
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Who cites it
42 citing papers in PubMed, 86 citations in OpenAlex.
- Circulating METRNL, Adipocytokines, and Insulin-Resistance Markers After Repeated Whole-Body Cryotherapy in Women of Different Ages.International journal of molecular sciences · 2026Article
- Underexplored terrain: effects of high priority environmental toxicants on skeletal muscle.Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- The Influence of Irisin on Selected Organs-The Liver, Kidneys, and Lungs: The Role of Physical Exercise.Cells · 2025Review
- Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling.Scientific reports · 2025Article
- E4bp4-Cyp3a11 axis in high-fat diet-induced obese mice with weight fluctuation.Nutrition & metabolism · 2024Article
- The role of novel adipokines in hepatocellular carcinoma progression: a mini review.American journal of cancer research · 2024Review
- The emerging roles of irisin in vascular calcification.Frontiers in endocrinology · 2024Review
- Impact of Paleo Diet on Body Composition, Carbohydrate and Fat Metabolism of Professional Handball Players.Nutrients · 2023Article
- Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity.International journal of molecular sciences · 2023Observational
- CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage.Frontiers in oncology · 2023Article
- Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction.International journal of general medicine · 2023Article
- Irisin: An anti-inflammatory exerkine in aging and redox-mediated comorbidities.Frontiers in endocrinology · 2023Review
- Atypical functions of xenobiotic receptors in lipid and glucose metabolism.Medical review (2021) · 2022Review
- Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.Molecular and cellular endocrinology · 2022Review
- Clinical Relevance of the Constitutive Androstane Receptor.Drug metabolism and disposition: the biological fate of chemicals · 2022Review
- Review
- Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease.Journal of clinical medicine · 2022Article
- Irisin at the crossroads of inter-organ communications: Challenge and implications.Frontiers in endocrinology · 2022Review
- Irisin, Exercise, and COVID-19.Frontiers in endocrinology · 2022Review
- The Emerging Role of Irisin in Cardiovascular Diseases.Journal of the American Heart Association · 2021Review
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Authors and funding
12 authors at 4 institutions in 1 country.
Li MoCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Jing ShenCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Qinhui LiuCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Yuwei ZhangCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Jiangying KuangCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Shiyun PuCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Shihai ChengCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Min ZouCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Wei JiangCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Changtao JiangCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Aijuan QuCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Jinhan HeCenter of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041 Sichuan, China; Department of Physiology and Pathophysiology (C.J.), School of Basic Medical Sciences, Peking University, Beijing 100871; and Department of Physiology and Pathophysiology (A.Q.), School of Basic Medical Sciences, Capital Medical University, Beijing 100069.
Capital Medical University · CNSichuan University · CNPeking University · CNWest China Hospital of Sichuan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing the level of uncoupling protein 1. In this study, we showed that activation of the nuclear receptor constitutive androstane receptor induced FNDC5 mRNA expression in the liver and increased the circulating level of irisin in mice. FNDC5/irisin is a direct transcriptional target of constitutive androstane receptor. Hepatic-released irisin functioned as a paracrine/autocrine factor that inhibited lipogenesis and gluconeogenesis via the Adenosine 5'-monophosphate (AMP)-activated protein kinase pathway. Adenovirus-overexpressed irisin improved hepatic steatosis and insulin resistance in genetic-induced obese mice. Irisin transgenic mice were also protected against high-fat diet-induced obesity and insulin resistance. In conclusion, our results reveal a novel pathway in regulating FNDC5/irisin expression and identify a physiological role for this hepatic hormone in glucose and lipid homeostasis.
Indexed as
Adenosine MonophosphateAdipocytesAMP-Activated Protein KinasesAnimalsConstitutive Androstane ReceptorDiet, High-FatFibronectinsGluconeogenesisGlucoseInsulin ResistanceLipid MetabolismLipogenesisLiverMaleMiceMice, Inbred C57BLAdenosine MonophosphateAMP-Activated Protein KinasesConstitutive Androstane ReceptorFibronectinsFNDC5 protein, mouseGlucoseReceptors, Cytoplasmic and NuclearRNA, Messenger
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